Aage Kristian Olsen Alstrup

Hypothalamic deep brain stimulation influences autonomic and limbic circuitry involved in the regulation of aggression and cardiocerebrovascular control in the Göttingen minipig

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Hypothalamic deep brain stimulation influences autonomic and limbic circuitry involved in the regulation of aggression and cardiocerebrovascular control in the Göttingen minipig. / Ettrup, K S; Sørensen, J C; Rodell, A; Alstrup, A K O; Bjarkam, C R.

In: Stereotactic and Functional Neurosurgery, Vol. 90, No. 5, 2012, p. 281-91.

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@article{b6d9981208f347979326754e3c26c341,
title = "Hypothalamic deep brain stimulation influences autonomic and limbic circuitry involved in the regulation of aggression and cardiocerebrovascular control in the G{\"o}ttingen minipig",
abstract = "BACKGROUND: Deep brain stimulation (DBS) in the ventral tuberal hypothalamus (VTH) is currently under investigation for the treatment of severe obesity. Stimulation impact on a number of closely related hypothalamic neural systems could potentially influence normal hypothalamic function and thereby generate adverse side effects.OBJECTIVE: To assess the feasibility and safety of VTH DBS in a non-primate large animal model.METHODS: In the VTH of 6 G{\"o}ttingen minipigs, quadropolar leads were implanted bilaterally (n = 2) or unilaterally (n = 4), using optimized MRI sequences allowing identification of major diencephalic landmarks. Heart rate, weight, behavior and nighttime locomotor activity were recorded throughout the study period. Two of the unilaterally implanted minipigs were examined with [15O]H2O positron emission tomography (PET) scans performed in DBS-off and DBS-on mode.RESULTS: VTH DBS elicited an amplitude-dependent increase in heart rate and transient aggressive behavior. PET demonstrated that VTH DBS caused a global increase in cerebral blood flow velocities and decreased mean transit time.CONCLUSIONS: VTH DBS results in behavioral and physiological changes, which may derive from activation of closely related limbic and autonomic networks. Caution and further studies of longer length should be requested before this procedure is used more widely in humans.",
keywords = "Aggression, Animals, Autonomic Nervous System, Cerebrovascular Circulation, Deep Brain Stimulation, Feasibility Studies, Female, Heart Rate, Hypothalamus, Limbic System, Models, Animal, Models, Neurological, Nerve Net, Pilot Projects, Swine, Swine, Miniature",
author = "Ettrup, {K S} and S{\o}rensen, {J C} and A Rodell and Alstrup, {A K O} and Bjarkam, {C R}",
note = "Copyright {\circledC} 2012 S. Karger AG, Basel.",
year = "2012",
doi = "10.1159/000338087",
language = "English",
volume = "90",
pages = "281--91",
journal = "Stereotactic and Functional Neurosurgery",
issn = "1011-6125",
publisher = "S. Karger AG",
number = "5",

}

RIS

TY - JOUR

T1 - Hypothalamic deep brain stimulation influences autonomic and limbic circuitry involved in the regulation of aggression and cardiocerebrovascular control in the Göttingen minipig

AU - Ettrup, K S

AU - Sørensen, J C

AU - Rodell, A

AU - Alstrup, A K O

AU - Bjarkam, C R

N1 - Copyright © 2012 S. Karger AG, Basel.

PY - 2012

Y1 - 2012

N2 - BACKGROUND: Deep brain stimulation (DBS) in the ventral tuberal hypothalamus (VTH) is currently under investigation for the treatment of severe obesity. Stimulation impact on a number of closely related hypothalamic neural systems could potentially influence normal hypothalamic function and thereby generate adverse side effects.OBJECTIVE: To assess the feasibility and safety of VTH DBS in a non-primate large animal model.METHODS: In the VTH of 6 Göttingen minipigs, quadropolar leads were implanted bilaterally (n = 2) or unilaterally (n = 4), using optimized MRI sequences allowing identification of major diencephalic landmarks. Heart rate, weight, behavior and nighttime locomotor activity were recorded throughout the study period. Two of the unilaterally implanted minipigs were examined with [15O]H2O positron emission tomography (PET) scans performed in DBS-off and DBS-on mode.RESULTS: VTH DBS elicited an amplitude-dependent increase in heart rate and transient aggressive behavior. PET demonstrated that VTH DBS caused a global increase in cerebral blood flow velocities and decreased mean transit time.CONCLUSIONS: VTH DBS results in behavioral and physiological changes, which may derive from activation of closely related limbic and autonomic networks. Caution and further studies of longer length should be requested before this procedure is used more widely in humans.

AB - BACKGROUND: Deep brain stimulation (DBS) in the ventral tuberal hypothalamus (VTH) is currently under investigation for the treatment of severe obesity. Stimulation impact on a number of closely related hypothalamic neural systems could potentially influence normal hypothalamic function and thereby generate adverse side effects.OBJECTIVE: To assess the feasibility and safety of VTH DBS in a non-primate large animal model.METHODS: In the VTH of 6 Göttingen minipigs, quadropolar leads were implanted bilaterally (n = 2) or unilaterally (n = 4), using optimized MRI sequences allowing identification of major diencephalic landmarks. Heart rate, weight, behavior and nighttime locomotor activity were recorded throughout the study period. Two of the unilaterally implanted minipigs were examined with [15O]H2O positron emission tomography (PET) scans performed in DBS-off and DBS-on mode.RESULTS: VTH DBS elicited an amplitude-dependent increase in heart rate and transient aggressive behavior. PET demonstrated that VTH DBS caused a global increase in cerebral blood flow velocities and decreased mean transit time.CONCLUSIONS: VTH DBS results in behavioral and physiological changes, which may derive from activation of closely related limbic and autonomic networks. Caution and further studies of longer length should be requested before this procedure is used more widely in humans.

KW - Aggression

KW - Animals

KW - Autonomic Nervous System

KW - Cerebrovascular Circulation

KW - Deep Brain Stimulation

KW - Feasibility Studies

KW - Female

KW - Heart Rate

KW - Hypothalamus

KW - Limbic System

KW - Models, Animal

KW - Models, Neurological

KW - Nerve Net

KW - Pilot Projects

KW - Swine

KW - Swine, Miniature

U2 - 10.1159/000338087

DO - 10.1159/000338087

M3 - Journal article

C2 - 22797692

VL - 90

SP - 281

EP - 291

JO - Stereotactic and Functional Neurosurgery

JF - Stereotactic and Functional Neurosurgery

SN - 1011-6125

IS - 5

ER -