Aage Kristian Olsen Alstrup

Animal models in fetal medicine and obstetrics

Research output: Contribution to book/anthology/report/proceedingBook chapterCommunication

Animal models remain essential to understand the fundamental mechanisms occurring in fetal medicine and obstetric diseases, such as intrauterine growth restriction, preeclampsia and gestational diabetes. These vary regarding the employed method used for induction of the disease, and vary regarding the animal characteristics (size, number of fetuses, placenta barrier type, etc). While none of these exactly mirrors the human condition, different pregnant animal models (mice, rats, guinea pigs, chinchillas, rabbits, sheep and pigs) are here described with respect to advantages and limitations. The ability to employ non-invasively diagnostics varies among species, specifically for ultrasound and MRI procedures. Management of feeding, handling, care and anesthesia are particularly important factors in the pregnant animal.
Original languageEnglish
Title of host publicationAnimal Models for Human Diseases
PublisherInTechOpen
Publication year2018
ISBN (Electronic)978-953-51-5440-2
Publication statusPublished - 2018

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