Aage Kristian Olsen Alstrup

An overview of the use of pigs in PET research

Research output: Contribution to conferenceConference abstract for conferenceResearch

Current interest in studying molecular processes as they occur in the living organism has accelerated the use of laboratory animals for imaging of novel radiolabeled compounds. In particular, PET has contributed to the development of radiolabeled compounds for assessing molecular processes. The dynamics of PET typically require a relatively large organ size and blood supply in order to properly evaluate radioligand binding kinetics. To fulfil these requirements, pigs have often been used in such studies. At least four factors have contributed to the ever-growing interest in using pigs for PET imaging. First, a wealth of information has become available concerning similarities of physiologic and pathologic processes in pigs and humans. Second, the size of most pig organs permits studies to be carried out in PET scanners otherwise designed for human use. Third, multiple blood samples can be drawn from pigs to carry out accurate metabolite analyses in studies of new PET radioligands. Fourth, pigs can easily be maintained in anaesthesia for long-term PET studies with multiple injections of radiotracers. Clearly, pigs have much to offer PET studies. In this presentation I will also give an overview over how pig studies in practice can be performed in human PET scanners.
Original languageEnglish
Publication year21 Nov 2014
Publication statusPublished - 21 Nov 2014
EventSPECT and PET imaging in porcine inflammation and infection models - Københavns Universitet, København, Denmark
Duration: 21 Nov 201421 Nov 2014

Conference

ConferenceSPECT and PET imaging in porcine inflammation and infection models
LocationKøbenhavns Universitet
CountryDenmark
CityKøbenhavn
Period21/11/201421/11/2014

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