Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain

Chun-Yan Wang, Tao Wang, Wei Zheng, Bao-Lu Zhao, Gorm Danscher, Yu-Hua Chen, Zhan-You Wang

    Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

    Abstract

    Abnormal zinc homeostasis is involved in β-amyloid (Aβ) plaque formation and, therefore, the zinc load is a contributing factor in Alzheimer's disease (AD). However, the involvement of zinc in amyloid precursor protein (APP) processing and Aβ deposition has not been well established in AD animal models in vivo.
    OriginalsprogEngelsk
    TidsskriftP L o S One
    Vol/bind5
    Nummer12
    Sider (fra-til)e15349
    ISSN1932-6203
    DOI
    StatusUdgivet - 1 jan. 2010

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