Xenoestrogenic activity in blood of European and Inuit populations.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Xenoestrogenic activity in blood of European and Inuit populations. / Bonefeld-Jørgensen, Eva Cecilie; Hjelmborg, Philip Sebastian; Reinert, Line S; Andersen, Birgitte Sloth; Lindh, Christian H; Hagmar, Lars; Giwercman, Aleksander; Erlandsen, Mogens; Manicardi, Gian-Carlo; Spano, Marcello; Toft, Gunnar; JPB.

I: Environmental Health: A Global Access Science Source, Bind 5, Nr. 1, 2006, s. 1-12.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Bonefeld-Jørgensen, EC, Hjelmborg, PS, Reinert, LS, Andersen, BS, Lindh, CH, Hagmar, L, Giwercman, A, Erlandsen, M, Manicardi, G-C, Spano, M, Toft, G & JPB 2006, 'Xenoestrogenic activity in blood of European and Inuit populations.', Environmental Health: A Global Access Science Source, bind 5, nr. 1, s. 1-12. https://doi.org/10.1186/1476-069X-5-12

APA

Bonefeld-Jørgensen, E. C., Hjelmborg, P. S., Reinert, L. S., Andersen, B. S., Lindh, C. H., Hagmar, L., Giwercman, A., Erlandsen, M., Manicardi, G-C., Spano, M., Toft, G., & JPB (2006). Xenoestrogenic activity in blood of European and Inuit populations. Environmental Health: A Global Access Science Source, 5(1), 1-12. https://doi.org/10.1186/1476-069X-5-12

CBE

Bonefeld-Jørgensen EC, Hjelmborg PS, Reinert LS, Andersen BS, Lindh CH, Hagmar L, Giwercman A, Erlandsen M, Manicardi G-C, Spano M, Toft G, JPB. 2006. Xenoestrogenic activity in blood of European and Inuit populations. Environmental Health: A Global Access Science Source. 5(1):1-12. https://doi.org/10.1186/1476-069X-5-12

MLA

Vancouver

Bonefeld-Jørgensen EC, Hjelmborg PS, Reinert LS, Andersen BS, Lindh CH, Hagmar L o.a. Xenoestrogenic activity in blood of European and Inuit populations. Environmental Health: A Global Access Science Source. 2006;5(1):1-12. https://doi.org/10.1186/1476-069X-5-12

Author

Bonefeld-Jørgensen, Eva Cecilie ; Hjelmborg, Philip Sebastian ; Reinert, Line S ; Andersen, Birgitte Sloth ; Lindh, Christian H ; Hagmar, Lars ; Giwercman, Aleksander ; Erlandsen, Mogens ; Manicardi, Gian-Carlo ; Spano, Marcello ; Toft, Gunnar ; JPB. / Xenoestrogenic activity in blood of European and Inuit populations. I: Environmental Health: A Global Access Science Source. 2006 ; Bind 5, Nr. 1. s. 1-12.

Bibtex

@article{0f246090127811dcbee902004c4f4f50,
title = "Xenoestrogenic activity in blood of European and Inuit populations.",
abstract = "BACKGROUND: Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups with varying POP exposure, and to evaluate correlations to the POP biomarkers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE). METHODS: The study included 358 men: Greenlandic Inuit's, Swedish fishermen, and Warsaw (Poland) and Kharkiv (Ukraine) inhabitants. Xenoestrogenicity of serum extracts alone (XER) and XER competitive (XERcomp) effect on 17beta-estradiol induced estrogen receptor (ER) transactivity were assessed in the hormone free, lipophilic serum fraction containing the POPs using the MVLN human breast cancer cell line. RESULTS: No agonistic XER activity was exhibited for Inuit serum samples, while 12 - 24% of the European samples had detectable agonistic XER activity. On the contrary, 71% of Inuit serum samples antagonized XERcomp compared to 7 - 30 % in the other regions. XER and XERcomp were not or weakly correlated to the two POP markers. XER activity of Inuit samples was negatively associated to levels of CB-153 and p,p'-DDE. For the Warsaw group a positive and negative correlation between XER and p,p'-DDE and estradiol equivalence level and CB-153 levels was found. CONCLUSION: No strong consistent association between xenoestrogenic net activity and the two POP markers was found. The results showed that the selected POP markers alone can not predict the integrated xenoestrogenic serum activity. Correlations to the POP markers were found at the extreme edge; the Inuit's and Warsaw study groups eliciting high frequency of samples with ER antagonistic and agonistic activity, respectively. We suggest that the variation in xenoestrogenic serum activity reflects differences in POP exposure mixture, genetic factors and/or life style factors.",
author = "Bonefeld-J{\o}rgensen, {Eva Cecilie} and Hjelmborg, {Philip Sebastian} and Reinert, {Line S} and Andersen, {Birgitte Sloth} and Lindh, {Christian H} and Lars Hagmar and Aleksander Giwercman and Mogens Erlandsen and Gian-Carlo Manicardi and Marcello Spano and Gunnar Toft and JPB",
year = "2006",
doi = "10.1186/1476-069X-5-12",
language = "English",
volume = "5",
pages = "1--12",
journal = "Environmental Health: A Global Access Science Source",
issn = "1476-069X",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Xenoestrogenic activity in blood of European and Inuit populations.

AU - Bonefeld-Jørgensen, Eva Cecilie

AU - Hjelmborg, Philip Sebastian

AU - Reinert, Line S

AU - Andersen, Birgitte Sloth

AU - Lindh, Christian H

AU - Hagmar, Lars

AU - Giwercman, Aleksander

AU - Erlandsen, Mogens

AU - Manicardi, Gian-Carlo

AU - Spano, Marcello

AU - Toft, Gunnar

AU - JPB, null

PY - 2006

Y1 - 2006

N2 - BACKGROUND: Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups with varying POP exposure, and to evaluate correlations to the POP biomarkers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE). METHODS: The study included 358 men: Greenlandic Inuit's, Swedish fishermen, and Warsaw (Poland) and Kharkiv (Ukraine) inhabitants. Xenoestrogenicity of serum extracts alone (XER) and XER competitive (XERcomp) effect on 17beta-estradiol induced estrogen receptor (ER) transactivity were assessed in the hormone free, lipophilic serum fraction containing the POPs using the MVLN human breast cancer cell line. RESULTS: No agonistic XER activity was exhibited for Inuit serum samples, while 12 - 24% of the European samples had detectable agonistic XER activity. On the contrary, 71% of Inuit serum samples antagonized XERcomp compared to 7 - 30 % in the other regions. XER and XERcomp were not or weakly correlated to the two POP markers. XER activity of Inuit samples was negatively associated to levels of CB-153 and p,p'-DDE. For the Warsaw group a positive and negative correlation between XER and p,p'-DDE and estradiol equivalence level and CB-153 levels was found. CONCLUSION: No strong consistent association between xenoestrogenic net activity and the two POP markers was found. The results showed that the selected POP markers alone can not predict the integrated xenoestrogenic serum activity. Correlations to the POP markers were found at the extreme edge; the Inuit's and Warsaw study groups eliciting high frequency of samples with ER antagonistic and agonistic activity, respectively. We suggest that the variation in xenoestrogenic serum activity reflects differences in POP exposure mixture, genetic factors and/or life style factors.

AB - BACKGROUND: Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups with varying POP exposure, and to evaluate correlations to the POP biomarkers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE). METHODS: The study included 358 men: Greenlandic Inuit's, Swedish fishermen, and Warsaw (Poland) and Kharkiv (Ukraine) inhabitants. Xenoestrogenicity of serum extracts alone (XER) and XER competitive (XERcomp) effect on 17beta-estradiol induced estrogen receptor (ER) transactivity were assessed in the hormone free, lipophilic serum fraction containing the POPs using the MVLN human breast cancer cell line. RESULTS: No agonistic XER activity was exhibited for Inuit serum samples, while 12 - 24% of the European samples had detectable agonistic XER activity. On the contrary, 71% of Inuit serum samples antagonized XERcomp compared to 7 - 30 % in the other regions. XER and XERcomp were not or weakly correlated to the two POP markers. XER activity of Inuit samples was negatively associated to levels of CB-153 and p,p'-DDE. For the Warsaw group a positive and negative correlation between XER and p,p'-DDE and estradiol equivalence level and CB-153 levels was found. CONCLUSION: No strong consistent association between xenoestrogenic net activity and the two POP markers was found. The results showed that the selected POP markers alone can not predict the integrated xenoestrogenic serum activity. Correlations to the POP markers were found at the extreme edge; the Inuit's and Warsaw study groups eliciting high frequency of samples with ER antagonistic and agonistic activity, respectively. We suggest that the variation in xenoestrogenic serum activity reflects differences in POP exposure mixture, genetic factors and/or life style factors.

U2 - 10.1186/1476-069X-5-12

DO - 10.1186/1476-069X-5-12

M3 - Journal article

C2 - 16674832

VL - 5

SP - 1

EP - 12

JO - Environmental Health: A Global Access Science Source

JF - Environmental Health: A Global Access Science Source

SN - 1476-069X

IS - 1

ER -