We Are Not Alone: The iMOP Initiative and Its Roles in a Biology- and Disease-Driven Human Proteome Project

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We Are Not Alone : The iMOP Initiative and Its Roles in a Biology- and Disease-Driven Human Proteome Project. / Tholey, Andreas; Taylor, Nicolas L.; Heazlewood, Joshua L.; Bendixen, Emøke.

I: Journal of Proteome Research, Bind 16, Nr. 12, 01.12.2017, s. 4273-4280.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

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Tholey, Andreas ; Taylor, Nicolas L. ; Heazlewood, Joshua L. ; Bendixen, Emøke. / We Are Not Alone : The iMOP Initiative and Its Roles in a Biology- and Disease-Driven Human Proteome Project. I: Journal of Proteome Research. 2017 ; Bind 16, Nr. 12. s. 4273-4280.

Bibtex

@article{fcc63f1c6e4743b4bec6537b8f4ed587,
title = "We Are Not Alone: The iMOP Initiative and Its Roles in a Biology- and Disease-Driven Human Proteome Project",
abstract = "Mapping of the human proteome has advanced significantly in recent years and will provide a knowledge base to accelerate our understanding of how proteins and protein networks can affect human health and disease. However, providing solutions to human health challenges will likely fail if insights are exclusively based on studies of human samples and human proteomes. In recent years, it has become evident that human health depends on an integrated understanding of the many species that make human life possible. These include the commensal microorganisms that are essential to human life, pathogens, and food species as well as the classic model organisms that enable studies of biological mechanisms. The Human Proteome Organization (HUPO) initiative on multiorganism proteomes (iMOP) works to support proteome research undertaken on nonhuman species that remain widely under-studied compared with the progress in human proteome research. This perspective argues the need for further research on multiple species that impact human life. We also present an update on recent progress in model organisms, microbiota, and food species, address the emerging problem of antibiotics resistance, and outline how iMOP activities could lead to a more inclusive approach for the human proteome project (HPP) to better support proteome research aimed at improving human health and furthering knowledge on human biology.",
keywords = "crops, farm animals, food safety, iMOP, microbiome, model organisms, One Health, pathogens, veterinary health, zoonosis",
author = "Andreas Tholey and Taylor, {Nicolas L.} and Heazlewood, {Joshua L.} and Em{\o}ke Bendixen",
year = "2017",
month = "12",
day = "1",
doi = "10.1021/acs.jproteome.7b00408",
language = "English",
volume = "16",
pages = "4273--4280",
journal = "Journal of Proteome Research",
issn = "1535-3893",
publisher = "AMER CHEMICAL SOC",
number = "12",

}

RIS

TY - JOUR

T1 - We Are Not Alone

T2 - The iMOP Initiative and Its Roles in a Biology- and Disease-Driven Human Proteome Project

AU - Tholey, Andreas

AU - Taylor, Nicolas L.

AU - Heazlewood, Joshua L.

AU - Bendixen, Emøke

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Mapping of the human proteome has advanced significantly in recent years and will provide a knowledge base to accelerate our understanding of how proteins and protein networks can affect human health and disease. However, providing solutions to human health challenges will likely fail if insights are exclusively based on studies of human samples and human proteomes. In recent years, it has become evident that human health depends on an integrated understanding of the many species that make human life possible. These include the commensal microorganisms that are essential to human life, pathogens, and food species as well as the classic model organisms that enable studies of biological mechanisms. The Human Proteome Organization (HUPO) initiative on multiorganism proteomes (iMOP) works to support proteome research undertaken on nonhuman species that remain widely under-studied compared with the progress in human proteome research. This perspective argues the need for further research on multiple species that impact human life. We also present an update on recent progress in model organisms, microbiota, and food species, address the emerging problem of antibiotics resistance, and outline how iMOP activities could lead to a more inclusive approach for the human proteome project (HPP) to better support proteome research aimed at improving human health and furthering knowledge on human biology.

AB - Mapping of the human proteome has advanced significantly in recent years and will provide a knowledge base to accelerate our understanding of how proteins and protein networks can affect human health and disease. However, providing solutions to human health challenges will likely fail if insights are exclusively based on studies of human samples and human proteomes. In recent years, it has become evident that human health depends on an integrated understanding of the many species that make human life possible. These include the commensal microorganisms that are essential to human life, pathogens, and food species as well as the classic model organisms that enable studies of biological mechanisms. The Human Proteome Organization (HUPO) initiative on multiorganism proteomes (iMOP) works to support proteome research undertaken on nonhuman species that remain widely under-studied compared with the progress in human proteome research. This perspective argues the need for further research on multiple species that impact human life. We also present an update on recent progress in model organisms, microbiota, and food species, address the emerging problem of antibiotics resistance, and outline how iMOP activities could lead to a more inclusive approach for the human proteome project (HPP) to better support proteome research aimed at improving human health and furthering knowledge on human biology.

KW - crops

KW - farm animals

KW - food safety

KW - iMOP

KW - microbiome

KW - model organisms

KW - One Health

KW - pathogens

KW - veterinary health

KW - zoonosis

UR - http://www.scopus.com/inward/record.url?scp=85037341964&partnerID=8YFLogxK

U2 - 10.1021/acs.jproteome.7b00408

DO - 10.1021/acs.jproteome.7b00408

M3 - Review

C2 - 28933156

AN - SCOPUS:85037341964

VL - 16

SP - 4273

EP - 4280

JO - Journal of Proteome Research

JF - Journal of Proteome Research

SN - 1535-3893

IS - 12

ER -