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Waking Up in Pain: a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Anders Mølgaard Rasmussen, Københavns Universitet, Syddansk Universitet
    • ,
  • Mette Helene Toft, Region Hovedstaden
    • ,
  • Hussein Nasser Awada, Københavns Universitet
    • ,
  • Jesper Dirks, Københavns Universitet
    • ,
  • Birgitte Brandsborg
  • Line Kirkegaard Rasmussen
    • ,
  • Ellen Kirkegaard
    • ,
  • Dorthe Hasfeldt-Hansen, Syddansk Universitet
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  • Thomas Egemose Larsen, Syddansk Universitet
    • ,
  • Georgios Charalampidis, Syddansk Universitet
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  • Emilie Louise Schjøtt Mørk, Region Hovedstaden
    • ,
  • Chirstine Linaa Rosager, Region Hovedstaden
    • ,
  • Idress Ahmad Salam, Aalborg Universitet
    • ,
  • Bodil Steen Rasmussen, Aalborg Universitet
    • ,
  • Marlene Jørgensen, Aalborg Universitet
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  • Martin Skjønnemand, Herlev og Gentofte Hospital
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  • Caterina Amanti Lund, Københavns Universitet
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  • Save Schroder, Region Syddanmark
    • ,
  • Johan Kløvgaard Sørensen
  • Christoffer Sølling
    • ,
  • Kristian Kraft Hansen, Aarhus Universitet
    • ,
  • Christina Kirkegaard Rasmussen, Syddansk Universitet
    • ,
  • Nick Phaff Steen, Syddansk Universitet
    • ,
  • Anne Staal Nielsen, Syddansk Universitet
    • ,
  • Anja Geisler, Københavns Universitet
    • ,
  • Kasper Storm Køppen, Københavns Universitet
    • ,
  • Maria Bolther Pælestik
  • Thorbjørn Grøfte
    • ,
  • Christian Sylvest Meyhoff, Region Hovedstaden
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  • Charlotte Loumann Kroh, Region Hovedstaden
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  • Amalie Prien Christensen, Region Hovedstaden
    • ,
  • Aleksander Fjeld Haugstvedt, Region Hovedstaden
    • ,
  • Maria Aagaard Hansen, Aarhus Universitet
    • ,
  • Christian Viggo Nielsen, Aarhus Universitet
    • ,
  • Bitten Dybdal, Københavns Universitet
    • ,
  • Lars Falcon, Københavns Universitet
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  • Daniel Hägi-Pedersen, Københavns Universitet
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  • Kristian Jauho, Københavns Universitet
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  • Henrik Wolsted, Københavns Universitet
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  • Christian Alves Kohler Pedersen, Sygehus Sønderjylland
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  • Trine Nyboe Sommer, Sygehus Sønderjylland
    • ,
  • Laurits Schou Kromberg, Københavns Universitet
    • ,
  • Danja Lykke Kristensen, Uiversity of Copenhagen
    • ,
  • Camilla Kara Svensson, Nykøbing Falster Sygehus
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  • Hans Fjeldsøe Nielsen, Nykøbing Falster Sygehus
    • ,
  • Martin Kryspin Sørensen, Københavns Universitet
    • ,
  • Stig Jacobsen, Københavns Universitet
    • ,
  • Martin Sundskard, Københavns Universitet
    • ,
  • Nicole Brahe, Københavns Universitet
    • ,
  • Karina Jakobsen, Region Sjælland
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  • Mette Skov Jensen, Region Sjælland
    • ,
  • Lillian Odder, Aalborg Universitetshospital
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  • Hansjörg Selter, Aalborg Universitetshospital
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  • Tróndur Høgnason Mohr, Landssjúkrahúsid Dronning Alexandrines Hospital
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  • Elin H Jensen, Landssjúkrahúsid Dronning Alexandrines Hospital
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  • Pernille Pia Jensen, Dronning Ingrids Hospital
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  • Christine Skjold, Bornholms Hospital
    • ,
  • Eske Kvanner Aasvang, Københavns Universitet

BACKGROUND: Acute and persistent pain after surgery is well described. However, no large-scale studies on immediate postoperative pain in the operating room (OR) exist, hindering potential areas of research to improve clinical outcomes. Thus, we aimed to describe the occurrence and severity of immediate postoperative pain in a large, unselected cohort.

METHODS: This was a prospective cohort study, encompassing all procedures in 31 public hospitals in the Danish Realm, during a 5-day period including the weekend. Data on procedures and anesthesia were collected and the main outcome was occurrence of moderate or severe pain in the OR. Secondary outcomes included pain, sedation and nausea in the OR or during the first 15 min in the postanesthesia care unit (PACU) including relevant risk factors. Descriptive and logistic regression statistics were used.

RESULTS: A total of 3675 procedures were included for analysis (87% inclusion rate). Moderate or severe pain occurred in 7.4% (95% CI 6.5% to 8.3%) of cases in the OR immediately after awakening, rising to 20.2% in the OR and/or PACU. Large intraprocedure and interprocedure variations occurred (0.0%-37.5%), and in 20% of cases with epidural-general anesthesia patients experienced moderate or severe pain. Independent risk factors were female sex, younger age, preoperative pain, daily opioid use and major surgical procedures.

CONCLUSION: Moderate or severe pain in the immediate postoperative phase occurred in 20% of all cases with procedure and anesthesiological technique variations, suggesting a need for identification of relevant procedure-specific risk factors and development of preventive treatments.

TRIAL REGISTRATION NUMBER: RoPR ID 43191.

OriginalsprogEngelsk
TidsskriftRegional Anesthesia and Pain Medicine
Vol/bind46
Nummer11
Sider (fra-til)948-953
Antal sider6
ISSN1098-7339
DOI
StatusUdgivet - nov. 2021

Bibliografisk note

© American Society of Regional Anesthesia & Pain Medicine 2021. No commercial re-use. See rights and permissions. Published by BMJ.

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