Vulvær intraepithelial neoplasi

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  • Signe Østergaard Hansen, Danmark
  • Christina Steen Vorbeck, Københavns Universitet, Danmark
  • Mette Meinert
Vulvar intraepithelial neoplasia
Vulvar intraepithelial neoplasia (VIN) is a rare but premalig­nant condition. VIN has two aetiological pathways: a human papillomavirus (HPV)-dependent pathway, which is a vulvar high-grade squamous intraepithelial lesion (HSIL), and an HPV-independent pathway, called differentiated VIN (d-VIN), associated with lichen sclerosus. d-VIN is more aggressive than vulvar HSIL. In case of symptoms, a biopsy should be performed. The recurrence risk is high: 25-50% regardless of treatment type. We recommend treatment with imiquimod as first choice to avoid mutilating surgery. Particular attention must be payed to immunosuppressed patients with VIN. HPV-vaccine can be discussed with patients with vulvar HSIL.
OriginalsprogDansk
ArtikelnummerV2170931
TidsskriftUgeskrift for Laeger
Vol/bind2018
Nummer180
Sider (fra-til)2-5
Antal sider4
ISSN0041-5782
StatusUdgivet - 1 maj 2018

    Forskningsområder

  • Vulvar Neoplasms, imiquimod, vulva dysplasi imiquimod

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