Visualization of thermally activated nanocarriers using in situ atomic force microscopy: Nanotechnology

M. D. Dong; K. A. Howard; D. Oupicky; H. Bisht; Jørgen Kjems; F. Besenbacher

doi:10.1088/0957-4484/18/18/185501

Visualization of thermally activated nanocarriers using in situ atomic force microscopy: Nanotechnology

M. D. Dong, K. A. Howard, D. Oupicky, H. Bisht, Jørgen Kjems, F. Besenbacher

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

3 Citationer (Scopus)

Abstract

Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.

Originalsprog	Engelsk
Artikelnummer	185501
Tidsskrift	Nanotechnology
Vol/bind	18
Nummer	18
ISSN	0957-4484
DOI	https://doi.org/10.1088/0957-4484/18/18/185501
Status	Udgivet - 2007

Adgang til dokumentet

10.1088/0957-4484/18/18/185501

Citationsformater

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abstract = "Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.",

author = "Dong, {M. D.} and Howard, {K. A.} and D. Oupicky and H. Bisht and J{\o}rgen Kjems and F. Besenbacher",

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AU - Dong, M. D.

AU - Howard, K. A.

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AU - Kjems, Jørgen

AU - Besenbacher, F.

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AB - Thermo-responsive nanocarriers aim to improve the delivery of drugs into target tissue by a process of size-mediated deposition activated by thermal stimuli. The direct imaging of thermally-induced changes in nanocarrier morphology was demonstrated using in situ liquid AFM over a nano-scale and temperature range relevant for clinical approaches. In situ AFM proved to be a unique method for investigating the dynamic conformational changes of individual nanoparticles, promoting its application in the future development of stimuli-responsive nanocarriers.

U2 - 10.1088/0957-4484/18/18/185501

DO - 10.1088/0957-4484/18/18/185501

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