Visualising spikes in source-space: rapid and efficient evaluation of magnetoencephalography

Sándor Beniczky; Lene Duez; Michael Scherg; Peter Orm Hansen; Hatice Tankisi; Per Christian Sidenius; Anne Sabers; Lars Hageman  Pinborg; Peter Uldall; Anders Fuglsang-Frederiksen

Visualising spikes in source-space: rapid and efficient evaluation of magnetoencephalography

Sándor Beniczky, Lene Duez, Michael Scherg, Peter Orm Hansen, Hatice Tankisi, Per Christian Sidenius, Anne Sabers, Lars Hageman Pinborg, Peter Uldall, Anders Fuglsang-Frederiksen

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Abstract

Objective: Reviewing magnetoencephalography (MEG) recordings is time-consuming: signals from the 306 MEG-sensors are typically reviewed divided into six arrays of 51 sensors each, thus browsing each recording six times in order to evaluate all signals. A novel method of reconstructing the MEG signals in source-space was developed using a source-montage of 29 brain-regions and two spatial components to remove magnetocardiographic (MKG) artefacts. Our objective was to evaluate the accuracy of reviewing MEG in source-space. Methods: In 60 consecutive patients with epilepsy, we prospectively evaluated the accuracy of reviewing the MEG signals in source-space as compared to the classical method of reviewing them in sensor-space. Results: All 46 spike-clusters identified in sensor-space were also identified in source-space. Two additional spike-clusters were identified in source-space. As 29 source-channels can be easily displayed simultaneously, MEG recordings had to be browsed only once. Yet, this yielded a global coverage of the recorded signals and enhanced detectability of epileptiform discharges because MKG-artefacts were suppressed and did not impede evaluation in source-space. Conclusions: Our results show that reviewing MEG recordings in source-space is accurate and much more rapid than the classical method of reviewing in sensor-space. Significance: This novel method facilitates the clinical use of MEG.

Originalsprog	Engelsk
Tidsskrift	Clinical Neurophysiology
Vol/bind	127
Nummer	2
Sider (fra-til)	1067-1072
Antal sider	6
ISSN	1388-2457
Status	Udgivet - 1 feb. 2016

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title = "Visualising spikes in source-space: rapid and efficient evaluation of magnetoencephalography",

abstract = "Objective: Reviewing magnetoencephalography (MEG) recordings is time-consuming: signals from the 306 MEG-sensors are typically reviewed divided into six arrays of 51 sensors each, thus browsing each recording six times in order to evaluate all signals. A novel method of reconstructing the MEG signals in source-space was developed using a source-montage of 29 brain-regions and two spatial components to remove magnetocardiographic (MKG) artefacts. Our objective was to evaluate the accuracy of reviewing MEG in source-space. Methods: In 60 consecutive patients with epilepsy, we prospectively evaluated the accuracy of reviewing the MEG signals in source-space as compared to the classical method of reviewing them in sensor-space. Results: All 46 spike-clusters identified in sensor-space were also identified in source-space. Two additional spike-clusters were identified in source-space. As 29 source-channels can be easily displayed simultaneously, MEG recordings had to be browsed only once. Yet, this yielded a global coverage of the recorded signals and enhanced detectability of epileptiform discharges because MKG-artefacts were suppressed and did not impede evaluation in source-space. Conclusions: Our results show that reviewing MEG recordings in source-space is accurate and much more rapid than the classical method of reviewing in sensor-space. Significance: This novel method facilitates the clinical use of MEG.",

keywords = "Artefact correction, Epileptiform activity, Magnetoencephalography, Source-montage, Source-space",

author = "S{\'a}ndor Beniczky and Lene Duez and Michael Scherg and Hansen, {Peter Orm} and Hatice Tankisi and Sidenius, {Per Christian} and Anne Sabers and Pinborg, {Lars Hageman} and Peter Uldall and Anders Fuglsang-Frederiksen",

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AU - Beniczky, Sándor

AU - Duez, Lene

AU - Scherg, Michael

AU - Hansen, Peter Orm

AU - Tankisi, Hatice

AU - Sidenius, Per Christian

AU - Sabers, Anne

AU - Pinborg, Lars Hageman

AU - Uldall, Peter

AU - Fuglsang-Frederiksen, Anders

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N2 - Objective: Reviewing magnetoencephalography (MEG) recordings is time-consuming: signals from the 306 MEG-sensors are typically reviewed divided into six arrays of 51 sensors each, thus browsing each recording six times in order to evaluate all signals. A novel method of reconstructing the MEG signals in source-space was developed using a source-montage of 29 brain-regions and two spatial components to remove magnetocardiographic (MKG) artefacts. Our objective was to evaluate the accuracy of reviewing MEG in source-space. Methods: In 60 consecutive patients with epilepsy, we prospectively evaluated the accuracy of reviewing the MEG signals in source-space as compared to the classical method of reviewing them in sensor-space. Results: All 46 spike-clusters identified in sensor-space were also identified in source-space. Two additional spike-clusters were identified in source-space. As 29 source-channels can be easily displayed simultaneously, MEG recordings had to be browsed only once. Yet, this yielded a global coverage of the recorded signals and enhanced detectability of epileptiform discharges because MKG-artefacts were suppressed and did not impede evaluation in source-space. Conclusions: Our results show that reviewing MEG recordings in source-space is accurate and much more rapid than the classical method of reviewing in sensor-space. Significance: This novel method facilitates the clinical use of MEG.

AB - Objective: Reviewing magnetoencephalography (MEG) recordings is time-consuming: signals from the 306 MEG-sensors are typically reviewed divided into six arrays of 51 sensors each, thus browsing each recording six times in order to evaluate all signals. A novel method of reconstructing the MEG signals in source-space was developed using a source-montage of 29 brain-regions and two spatial components to remove magnetocardiographic (MKG) artefacts. Our objective was to evaluate the accuracy of reviewing MEG in source-space. Methods: In 60 consecutive patients with epilepsy, we prospectively evaluated the accuracy of reviewing the MEG signals in source-space as compared to the classical method of reviewing them in sensor-space. Results: All 46 spike-clusters identified in sensor-space were also identified in source-space. Two additional spike-clusters were identified in source-space. As 29 source-channels can be easily displayed simultaneously, MEG recordings had to be browsed only once. Yet, this yielded a global coverage of the recorded signals and enhanced detectability of epileptiform discharges because MKG-artefacts were suppressed and did not impede evaluation in source-space. Conclusions: Our results show that reviewing MEG recordings in source-space is accurate and much more rapid than the classical method of reviewing in sensor-space. Significance: This novel method facilitates the clinical use of MEG.

KW - Artefact correction

KW - Epileptiform activity

KW - Magnetoencephalography

KW - Source-montage

KW - Source-space

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Visualising spikes in source-space: rapid and efficient evaluation of magnetoencephalography

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