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Ventro-dorsal Hippocampal Pathway Gates Novelty-Induced Contextual Memory Formation

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  • Felipe Fredes
  • Maria Alejandra Silva, Institute of Science and Technology Austria
  • ,
  • Peter Koppensteiner, Institute of Science and Technology Austria
  • ,
  • Kenta Kobayashi, National Institutes of Natural Sciences - National Institute for Physiological Sciences
  • ,
  • Maximilian Joesch, Institute of Science and Technology Austria
  • ,
  • Ryuichi Shigemoto, Institute of Science and Technology Austria

Novelty facilitates memory formation and is detected by both the dorsal and ventral hippocampus. Although dentate granule cells (GCs) in the dorsal hippocampus are known to mediate the formation of novelty-induced contextual memories, the required pathways and mechanisms remain unclear. Here we demonstrate that a powerful excitatory pathway from mossy cells (MCs) in the ventral hippocampus to dorsal GCs is necessary and sufficient for driving dorsal GC activation in novel environment exploration. In vivo Ca2+ imaging in freely moving mice indicated that this pathway relays environmental novelty. Furthermore, manipulation of ventral MC activity bidirectionally regulates novelty-induced contextual memory acquisition. Our results show that ventral MC activity gates contextual memory formation through an intra-hippocampal interaction activated by environmental novelty.

TidsskriftCurrent Biology
Sider (fra-til)25-38.e5
StatusUdgivet - jan. 2021

Bibliografisk note

Funding Information:
We thank Peter Jonas and Peter Somogyi for critically reading the manuscript, Satoshi Kida for helpful discussion, Taijia Makinen for providing the Prox1-creERT2 mouse line, and Hiromu Yawo for the VAMP2-Venus construct. We also thank Vivek Jayaraman, Ph.D.; Rex A. Kerr, Ph.D.; Douglas S. Kim, Ph.D.; Loren L. Looger, Ph.D.; and Karel Svoboda, Ph.D. from the GENIE Project, Janelia Farm Research Campus, Howard Hughes Medical Institute for the viral constructs used for GCaMP6s expression. We also thank Jacqueline Montanaro, Vanessa Zheden, David Kleindienst, and Laura Burnett for technical assistance, as well as Robert Beattie for imaging assistance. This work was supported by a European Research Council Advanced Grant 694539 to R.S.

Publisher Copyright:
© 2020 The Author(s)

Copyright 2021 Elsevier B.V., All rights reserved.

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