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Venous thromboembolism and risk of depression: a population-based cohort study

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  • Helle Jørgensen, UiT The Arctic University of Norway, University Hospital of North Norway
  • ,
  • Erzsébet Horváth-Puhó
  • Kristina Laugesen
  • Sigrid K Braekkan, UiT The Arctic University of Norway, University Hospital of North Norway, Norge
  • John-Bjarne Hansen, UiT The Arctic University of Norway, University Hospital of North Norway
  • ,
  • Henrik Toft Sørensen

Background: The psychologic consequences of acute venous thromboembolism (VTE) have not been investigated in depth. Objectives: We aimed to examine the association between VTE and the risk of subsequent depression. Methods: Using Danish nationwide registries, we established a population-based cohort of 64 596 individuals with incident VTE during 1996 to 2016 and a comparison cohort (n = 322 999) selected randomly from the general population and individually matched by birth year, sex, and calendar year of VTE. The participants were followed up for 3 years, and depression was defined as any hospital diagnosis of depression or ≥1 prescription for antidepressants. Incidence rates were computed as the number of events per 1000 person-years, and hazard ratios with 95% CIs were computed as estimates of the risk conferred by VTE using the comparison cohort as reference. We estimated absolute risks using cumulative incidence functions, treating death as a competing event. Results: Depression was observed in 6225 individuals after VTE and 16 363 members of the comparison cohort (incidence rates of 44.4 and 19.4 per 1000 person-years, respectively). The absolute risk of depression was 10.3% (95% CI, 10.1%-10.6%) in the VTE cohort and 5.6% (95% CI, 5.5%-5.6%) in the comparison cohort, corresponding to 4.7 excess cases of depression per 100 individuals with VTE. VTE was associated with a 2.35-fold (95% CI, 2.28-2.43) increased risk of depression compared with that in the comparison cohort. The association was attenuated after adjustments for socioeconomic status and comorbidities (hazard ratio, 1.91; 95% CI, 1.85-1.97). Conclusion: VTE was associated with an increased risk of depression after adjustment for comorbidities.

TidsskriftJournal of Thrombosis and Haemostasis
Sider (fra-til)953-962
Antal sider10
StatusUdgivet - apr. 2023

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