Variations on a theme: Crystal forms of the amino-acid transporter MhsT

Caroline Neumann, Dorota Focht, Sofia Trampari, Joseph A. Lyons, Poul Nissen*

*Corresponding author af dette arbejde

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Abstract

The bacterial amino-acid transporter MhsT from the SLC6A family has been crystallized in complex with different substrates in order to understand the determinants of the substrate specificity of the transporter. Surprisingly, crystals of the different MhsT-substrate complexes showed interrelated but different crystal-packing arrangements. Space-group assignment and structure determination of these different crystal forms present challenging combinations of pseudosymmetry, twinning and translational noncrystallographic symmetry.

OriginalsprogEngelsk
TidsskriftActa Crystallographica Section F: Structural Biology Communications
Vol/bind78
NummerPart 8
Sider (fra-til)297-305
Antal sider9
ISSN2053-230X
DOI
StatusUdgivet - aug. 2022

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