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Variations on a theme: Crystal forms of the amino-acid transporter MhsT

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The bacterial amino-acid transporter MhsT from the SLC6A family has been crystallized in complex with different substrates in order to understand the determinants of the substrate specificity of the transporter. Surprisingly, crystals of the different MhsT-substrate complexes showed interrelated but different crystal-packing arrangements. Space-group assignment and structure determination of these different crystal forms present challenging combinations of pseudosymmetry, twinning and translational noncrystallographic symmetry.

TidsskriftActa Crystallographica Section F: Structural Biology Communications
NummerPart 8
Sider (fra-til)297-305
Antal sider9
StatusUdgivet - aug. 2022

Bibliografisk note

Funding Information:
The following funding is acknowledged: Lundbeckfonden (scholarship No. R208-2015-3225 to Caroline Neumann), Fellow grant No. R335-2019-2053 (to Joseph A. Lyons), research grants Nos. R155-2015-2666, R328-2019-546 and R248-2016-2518 (to Poul Nissen), Novo Nordisk Foundation research grant No. NNF19OC0054875 (to Poul Nissen), and European Union Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement (training network RAMP No. 722687 with a PhD scholarship to Sofia Trampari).

Publisher Copyright:
© 2022 International Union of Crystallography. All rights reserved.

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