Validation methods for encapsulated faecal microbiota transplantation: a scoping review

Nina Rågård; Simon Mark Dahl Baumwall; Sara Ellegaard Paaske; Mette Mejlby Hansen; Katrine Lundby Høyer; Susan Mikkelsen; Christian Erikstrup; Jens Frederik Dahlerup; Christian Lodberg Hvas

doi:10.1177/17562848251314820

Validation methods for encapsulated faecal microbiota transplantation: a scoping review

Nina Rågård, Simon Mark Dahl Baumwall, Sara Ellegaard Paaske, Mette Mejlby Hansen, Katrine Lundby Høyer, Susan Mikkelsen, Christian Erikstrup, Jens Frederik Dahlerup, Christian Lodberg Hvas^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

Abstract

A comprehensive evaluation of quality aspects to consider when developing encapsulated donor faeces for faecal microbiota transplantation Faecal microbiota transplantation (FMT) is a life-saving therapy, based on the transfer of intestinal microbiota from a healthy donor to a patient to treat disease. Encapsulation of donor faeces eases the application of FMT, but methods to evaluate the quality of encapsulated FMT are not standardised. Based on a systematic literature review, we here provide a comprehensive overview of factors that may influence the quality of encapsulated FMT. We describe three main domains that together form a model for standardisation: 1. Processing (donor selection and processing protocol), 2. Content analysis (microbiota measures and dose measures) and 3. Clinical effect (engraftment and clinical outcomes). These domains may be addressed in future studies that report the use of encapsulated FMT.

Originalsprog	Engelsk
Tidsskrift	Therapeutic Advances in Gastroenterology
Vol/bind	18
Antal sider	25
ISSN	1756-283X
DOI	https://doi.org/10.1177/17562848251314820
Status	Udgivet - 1 jan. 2025

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10.1177/17562848251314820Licens: CC BY

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title = "Validation methods for encapsulated faecal microbiota transplantation: a scoping review",

abstract = "A comprehensive evaluation of quality aspects to consider when developing encapsulated donor faeces for faecal microbiota transplantation Faecal microbiota transplantation (FMT) is a life-saving therapy, based on the transfer of intestinal microbiota from a healthy donor to a patient to treat disease. Encapsulation of donor faeces eases the application of FMT, but methods to evaluate the quality of encapsulated FMT are not standardised. Based on a systematic literature review, we here provide a comprehensive overview of factors that may influence the quality of encapsulated FMT. We describe three main domains that together form a model for standardisation: 1. Processing (donor selection and processing protocol), 2. Content analysis (microbiota measures and dose measures) and 3. Clinical effect (engraftment and clinical outcomes). These domains may be addressed in future studies that report the use of encapsulated FMT.",

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AU - Rågård, Nina

AU - Baumwall, Simon Mark Dahl

AU - Paaske, Sara Ellegaard

AU - Hansen, Mette Mejlby

AU - Høyer, Katrine Lundby

AU - Mikkelsen, Susan

AU - Erikstrup, Christian

AU - Dahlerup, Jens Frederik

AU - Hvas, Christian Lodberg

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N2 - A comprehensive evaluation of quality aspects to consider when developing encapsulated donor faeces for faecal microbiota transplantation Faecal microbiota transplantation (FMT) is a life-saving therapy, based on the transfer of intestinal microbiota from a healthy donor to a patient to treat disease. Encapsulation of donor faeces eases the application of FMT, but methods to evaluate the quality of encapsulated FMT are not standardised. Based on a systematic literature review, we here provide a comprehensive overview of factors that may influence the quality of encapsulated FMT. We describe three main domains that together form a model for standardisation: 1. Processing (donor selection and processing protocol), 2. Content analysis (microbiota measures and dose measures) and 3. Clinical effect (engraftment and clinical outcomes). These domains may be addressed in future studies that report the use of encapsulated FMT.

AB - A comprehensive evaluation of quality aspects to consider when developing encapsulated donor faeces for faecal microbiota transplantation Faecal microbiota transplantation (FMT) is a life-saving therapy, based on the transfer of intestinal microbiota from a healthy donor to a patient to treat disease. Encapsulation of donor faeces eases the application of FMT, but methods to evaluate the quality of encapsulated FMT are not standardised. Based on a systematic literature review, we here provide a comprehensive overview of factors that may influence the quality of encapsulated FMT. We describe three main domains that together form a model for standardisation: 1. Processing (donor selection and processing protocol), 2. Content analysis (microbiota measures and dose measures) and 3. Clinical effect (engraftment and clinical outcomes). These domains may be addressed in future studies that report the use of encapsulated FMT.

KW - capsules administration and dosage

KW - faecal microbiota transplantation methods

KW - faeces

KW - humans

KW - microbiology

KW - validation studies

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SN - 1756-283X

VL - 18

JO - Therapeutic Advances in Gastroenterology

JF - Therapeutic Advances in Gastroenterology

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Validation methods for encapsulated faecal microbiota transplantation: a scoping review

Abstract

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