Utilization of biomarkers as predictors of skeletal muscle mitochondrial content after physiological intervention and in clinical settings

TY - JOUR

T1 - Utilization of biomarkers as predictors of skeletal muscle mitochondrial content after physiological intervention and in clinical settings

AU - Groennebaek, Thomas

AU - Nielsen, Joachim

AU - Jespersen, Nichlas Riise

AU - Botker, Hans Erik

AU - de Paoli, Frank V

AU - Miller, Benjamin F

AU - Vissing, Kristian

PY - 2020/6

Y1 - 2020/6

N2 - The measurement of mitochondrial content is essential for bioenergetic research, as it provides a tool to evaluate whether changes in mitochondrial function are strictly due to changes in content or other mechanisms that influence function. In this perspective, we argue that commonly used biomarkers of mitochondrial content may possess limited utility for capturing changes in content with physiological intervention. Moreover, we argue that they may not provide reliable estimates of content in certain pathological situations. Finally, we discuss potential solutions to overcome issues related to the utilization of biomarkers of mitochondrial content. Shedding light on this important issue will hopefully aid conclusions about the mitochondrial structure-function relationship.

AB - The measurement of mitochondrial content is essential for bioenergetic research, as it provides a tool to evaluate whether changes in mitochondrial function are strictly due to changes in content or other mechanisms that influence function. In this perspective, we argue that commonly used biomarkers of mitochondrial content may possess limited utility for capturing changes in content with physiological intervention. Moreover, we argue that they may not provide reliable estimates of content in certain pathological situations. Finally, we discuss potential solutions to overcome issues related to the utilization of biomarkers of mitochondrial content. Shedding light on this important issue will hopefully aid conclusions about the mitochondrial structure-function relationship.

KW - Bioenergetics

KW - Biomarkers

KW - Chronic disease

KW - Citrate synthase

KW - Exercise

UR - http://www.scopus.com/inward/record.url?scp=85085905355&partnerID=8YFLogxK

U2 - 10.1152/ajpendo.00101.2020

DO - 10.1152/ajpendo.00101.2020

M3 - Journal article

C2 - 32255679

SN - 1522-1555

VL - 318

SP - E886-E889

JO - A J P: Endocrinology and Metabolism (Online)

JF - A J P: Endocrinology and Metabolism (Online)

IS - 6

ER -