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Use of prescription drugs in the older adult population-a nationwide pharmacoepidemiological study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Line Due Christensen
  • Mette Reilev, Syddansk Universitet
  • ,
  • Helle Gybel Juul-Larsen, Københavns Universitet
  • ,
  • Lillian Mørch Jørgensen, Københavns Universitet
  • ,
  • Susanne Kaae, Section for Social and Clinical Pharmacy, Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
  • ,
  • Ove Andersen, Københavns Universitet, Emergency Department, Copenhagen University Hospital Hvidore, Hvidovre, Denmark.
  • ,
  • Anton Pottegård, Syddansk Universitet
  • ,
  • Janne Petersen, Københavns Universitet, Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Medicine, Aalborg University, Aalborg, Denmark.

PURPOSE: Multi-morbidity and polypharmacy are common among older people. It is essential to provide a better understanding of the complexity of prescription drug use among older adults to optimise rational pharmacotherapy. Population-based utilisation data in this age group is limited. Using the Danish nationwide health registries, we aimed to characterise drug use among Danish individuals ≥ 60 years.

METHODS: This is a descriptive population-based study assessing drug prescription patterns in 2015 in the full Danish population aged ≥ 60 years. The use of specific therapeutic subgroups and chemical subgroups and its dependence on age were described using descriptive statistics. Profiles of drug combination patterns were evaluated using latent class analysis.

RESULTS: We included 1,424,775 residents (median age 70 years, 53% women). Of all the older adults, 89% filled at least one prescription during 2015. The median number of drug groups used was five per person. The most used single drug groups were paracetamol and analogues (34%), statins (33%) and platelet aggregation inhibitors (24%). Eighteen drug profiles with different drug combination patterns were identified. One drug profile with expected use of zero drugs and 11 drug profiles expected to receive more than five different therapeutic subgroup drugs were identified.

CONCLUSION: The use of drugs is extensive both at the population level and increasing with age at an individual level. Separating the population into different homogenous groups related to drug use resulted in 18 different drug profiles, of which 11 drug profiles received on average more than five different therapeutic subgroup drugs.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Pharmacology
Vol/bind75
Nummer8
Sider (fra-til)1125-1133
Antal sider9
ISSN0031-6970
DOI
StatusUdgivet - aug. 2019
Eksternt udgivetJa

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