Use of copeptin for rapid rule-out of acute myocardial infarction

TY - JOUR

T1 - Use of copeptin for rapid rule-out of acute myocardial infarction

AU - Mueller, Christian

AU - Möckel, Martin

AU - Giannitsis, Evangelos

AU - Huber, Kurt

AU - Mair, Johannes

AU - Plebani, Mario

AU - Thygesen, Kristian

AU - Jaffe, Allan S

AU - Lindahl, Bertil

AU - ESC Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Copeptin is currently understood as a quantitative marker of endogenous stress. It rises rapidly in multiple acute disorders including acute myocardial infarction. As a single variable, it has only modest diagnostic accuracy for acute myocardial infarction. However, the use of copeptin within a dual-marker strategy together with conventional cardiac troponin increases the diagnostic accuracy and particularly the negative predictive value of cardiac troponin alone for acute myocardial infarction. The rapid rule-out of acute myocardial infarction is the only application in acute cardiac care mature enough to merit consideration for routine clinical care. However, the dual-marker approach seems to provide only very small incremental value when used in combination with sensitive or high-sensitivity cardiac troponin assays. This review aims to update and educate regarding the potential and the procedural details, as well as the caveats and challenges of using copeptin in clinical practice.

AB - Copeptin is currently understood as a quantitative marker of endogenous stress. It rises rapidly in multiple acute disorders including acute myocardial infarction. As a single variable, it has only modest diagnostic accuracy for acute myocardial infarction. However, the use of copeptin within a dual-marker strategy together with conventional cardiac troponin increases the diagnostic accuracy and particularly the negative predictive value of cardiac troponin alone for acute myocardial infarction. The rapid rule-out of acute myocardial infarction is the only application in acute cardiac care mature enough to merit consideration for routine clinical care. However, the dual-marker approach seems to provide only very small incremental value when used in combination with sensitive or high-sensitivity cardiac troponin assays. This review aims to update and educate regarding the potential and the procedural details, as well as the caveats and challenges of using copeptin in clinical practice.

KW - Journal Article

UR - http://www.scopus.com/inward/record.url?scp=85028522633&partnerID=8YFLogxK

U2 - 10.1177/2048872617710791

DO - 10.1177/2048872617710791

M3 - Journal article

C2 - 28593800

SN - 2048-8726

VL - 7

SP - 570

EP - 576

JO - European Heart Journal: Acute Cardiovascular Care

JF - European Heart Journal: Acute Cardiovascular Care

IS - 6

ER -