Abstract
Urogenital reconstructive surgery
Lotte Kaasgaard Jakobsen1
Professor Henning Olsen1
Overlæge Gitte Hvistendahl1
Professor Karl-Erik Andersson2
1 – Dept. of Urology, Aarhus University Hospital
2 – Dept. of Gynecology and Obstetrics, Aarhus University hospital
Background:
Congenital obstruction of the lower urinary tract causes voiding disabilities, renal failure and chronic bladder changes. Children with such malformations often require extensive treatment, and will experience side effects and not always satisfactory results.
Aim:
To develop an animal model of congenital infravesical obstruction, and utilise it to characterise changes caused by obstruction and effects of different treatment options.
Material and methods:
Four groups of swine will be investigated. Urethral obstruction will be created surgically in groups 2-4. After 4 weeks continuous unloading will be performed by vesicostomy in group 3, and intermittent unloading by urethrostomy in group 4. Group 2 will not be unloaded and serve as continously obstructed controls, whilst group 1 serves as sham-operated, non-obstructed controls. Urodynamic assessment will be performed and samples of urine, blood and bladder tissue will be collected.
To supplement the experimental studies we will evaluate patients with posterior urethral valves, and compare the effects of obstruction seen in these patients with the effects observed in the animal model.
Bladder tissue from fetal pigs will be investigated, comparing the properties of the fetal bladder to those of the bladder from young pigs used in the animal model.
Results:
By further characterising the effect of congenital obstruction, regarding urodynamic properties of the bladder and structural changes in the bladder tissue and comparing the results after relief of obstruction by continous or intermittent means, we hope to make it easier to choose which treatment to offer the patients. By establishing a solid animal model of congenital infravesical obstruction, we expect to make way for development of better treatments of a rare, but serious condition.
Lotte Kaasgaard Jakobsen1
Professor Henning Olsen1
Overlæge Gitte Hvistendahl1
Professor Karl-Erik Andersson2
1 – Dept. of Urology, Aarhus University Hospital
2 – Dept. of Gynecology and Obstetrics, Aarhus University hospital
Background:
Congenital obstruction of the lower urinary tract causes voiding disabilities, renal failure and chronic bladder changes. Children with such malformations often require extensive treatment, and will experience side effects and not always satisfactory results.
Aim:
To develop an animal model of congenital infravesical obstruction, and utilise it to characterise changes caused by obstruction and effects of different treatment options.
Material and methods:
Four groups of swine will be investigated. Urethral obstruction will be created surgically in groups 2-4. After 4 weeks continuous unloading will be performed by vesicostomy in group 3, and intermittent unloading by urethrostomy in group 4. Group 2 will not be unloaded and serve as continously obstructed controls, whilst group 1 serves as sham-operated, non-obstructed controls. Urodynamic assessment will be performed and samples of urine, blood and bladder tissue will be collected.
To supplement the experimental studies we will evaluate patients with posterior urethral valves, and compare the effects of obstruction seen in these patients with the effects observed in the animal model.
Bladder tissue from fetal pigs will be investigated, comparing the properties of the fetal bladder to those of the bladder from young pigs used in the animal model.
Results:
By further characterising the effect of congenital obstruction, regarding urodynamic properties of the bladder and structural changes in the bladder tissue and comparing the results after relief of obstruction by continous or intermittent means, we hope to make it easier to choose which treatment to offer the patients. By establishing a solid animal model of congenital infravesical obstruction, we expect to make way for development of better treatments of a rare, but serious condition.
| Originalsprog | Engelsk |
|---|---|
| Publikationsdato | 23 jan. 2015 |
| Status | Udgivet - 23 jan. 2015 |
| Begivenhed | PhD day 2015 - Aarhus University, Danmark Varighed: 23 jan. 2015 → 23 jan. 2015 |
Konference
| Konference | PhD day 2015 |
|---|---|
| Land/Område | Danmark |
| By | Aarhus University |
| Periode | 23/01/2015 → 23/01/2015 |
Emneord
- Urinvejskirurgi