Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men

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DOI

  • Thea Emily Benson
  • ,
  • Anne Gaml-Sørensen
  • Andreas Ernst
  • Nis Brix
  • Karin Sørig Hougaard, National Research Centre for the Working Environment, Københavns Universitet, Danmark
  • Katia Keglberg Hærvig, Københavns Universitet, Bispebjerg and Frederiksberg Hospital, Danmark
  • Jens Peter Ellekilde Bonde, Københavns Universitet, Bispebjerg and Frederiksberg Hospital
  • ,
  • Sandra Søgaard Tøttenborg, Bispebjerg and Frederiksberg Hospital, Danmark
  • Christian H Lindh, Lund University, Sverige
  • Cecilia Høst Ramlau-Hansen
  • Gunnar Toft

Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross-sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18-20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile-divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre-pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.

OriginalsprogEngelsk
Artikelnummer1742
TidsskriftInternational Journal of Environmental Research and Public Health
Vol/bind18
Nummer4
Antal sider12
ISSN1661-7827
DOI
StatusUdgivet - feb. 2021

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