Unmet therapeutic, educational and scientific needs in parathyroid disorders: Consensus Statement from the first Euroepan Society of Endocrinology Workshop (PARAT)

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Jens Bollerslev, Universitetet i Oslo
  • ,
  • Camilla Schalin-Jäntti, Helsinki University Central Hospital
  • ,
  • Lars Rejnmark
  • Heide Siggelkow, University of Göttingen
  • ,
  • Hans Morreau, Department of Human Genetics, Leiden University Medical Center (LUMC).
  • ,
  • Rajesh Thakker, Oxford University, Oxford, UK.
  • ,
  • Antonio Sitges-Serra, Autonomous University of Barcelona
  • ,
  • Filomena Cetani, University of Pisa
  • ,
  • Claudio Marcocci, University of Pisa
  • ,
  • PARAT Workshop Group

PARAT, a new European Society of Endocrinology program, aims to identify unmet scientific and educational needs of parathyroid disorders, such as primary hyperparathyroidism (PHPT), including parathyroid cancer (PC), and hypoparathyroidism (HypoPT). The discussions and consensus statements from the first PARAT workshop (September 2018) are reviewed. PHPT has a high prevalence in Western communities, PHPT has a high prevalence in Western communities, yet evidence is sparse concerning the natural history and whether morbidity and long-term outcomes are related to hypercalcemia or plasma PTH concentrations, or both. Cardiovascular mortality and prevalence of low energy fractures are increased, whereas Quality of Life is decreased, although their reversibility by treatment of PHPT has not been convincingly demonstrated. PC is a rare cause of PHPT, with an increasing incidence, and international collaborative studies are required to advance knowledge of the genetic mechanisms, biomarkers for disease activity, and optimal treatments. For example, ~20% of PCs demonstrate high mutational burden, and identifying targetable DNA variations, gene amplifications and gene fusions may facilitate personalized care, such as different forms of immunotherapy or targeted therapy. HypoPT, a designated orphan disease, is associated with a high risk of symptoms and complications. Most cases are secondary to neck surgery. However, there is a need to better understand the relation between disease biomarkers and intellectual function, and to establish the role of PTH in target tissues, as these may facilitate the appropriate use of PTH substitution therapy. Management of parathyroid disorders is challenging, and PARAT has highlighted the need for international transdisciplinary scientific and educational studies in advancing in this field.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Endocrinology
Vol/bind181
Nummer3
Sider (fra-til)P1-P19
Antal sider19
ISSN0804-4643
DOI
StatusUdgivet - 2019

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