TY - CHAP
T1 - Unlocking the memory vault
T2 - Dopamine, novelty, and memory consolidation in the hippocampus
AU - Takeuchi, Tomonori
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024. All rights reserved.
PY - 2024/4/25
Y1 - 2024/4/25
N2 - Most everyday memories, including numerous episodic memories formed automatically in the hippocampus, are forgotten. However, some memories are retained for extended periods through a memory stabilization process known as cellular or initial memory consolidation. Notably, in both animals and humans, the retention of everyday memories is enhanced during novel experiences occurring shortly before or after memory encoding, a process known as synaptic tagging and capture (STC). A growing body of evidence suggests that dopamine signaling via D1 /D 5 receptors in the hippocampus is crucial for the persistence of synaptic plasticity and memory, highlighting its significant role in novelty-associated memory enhancement. This chapter presents an overview of key findings related to the persistence of synaptic plasticity and memory in the hippocampus through hippocampal D1 /D5 receptor dependency, with special emphasis on the emerging role of the locus coeruleus (LC) in novelty-associated dopamine-dependent memory consolidation. Furthermore, two distinct dopaminergic systems are explored (the ventral tegmental area (VTA)-hippocampal and LC-hippocampal systems), and the specialization mechanisms of each system in different memory consolidation processes are discussed. Additionally, the anatomical and molecular foundations of D1 /D5 receptor-mediated signaling in the LC-hippocampal system are examined. Finally, the molecular mechanisms possibly underlying distinct novelty-associated memory enhancement are discussed, including the involvement of plasticity-related proteins (PRPs) in the stabilization of structural and functional changes at potentiated synapses, culminating in initial memory consolidation in the hippocampus.
AB - Most everyday memories, including numerous episodic memories formed automatically in the hippocampus, are forgotten. However, some memories are retained for extended periods through a memory stabilization process known as cellular or initial memory consolidation. Notably, in both animals and humans, the retention of everyday memories is enhanced during novel experiences occurring shortly before or after memory encoding, a process known as synaptic tagging and capture (STC). A growing body of evidence suggests that dopamine signaling via D1 /D 5 receptors in the hippocampus is crucial for the persistence of synaptic plasticity and memory, highlighting its significant role in novelty-associated memory enhancement. This chapter presents an overview of key findings related to the persistence of synaptic plasticity and memory in the hippocampus through hippocampal D1 /D5 receptor dependency, with special emphasis on the emerging role of the locus coeruleus (LC) in novelty-associated dopamine-dependent memory consolidation. Furthermore, two distinct dopaminergic systems are explored (the ventral tegmental area (VTA)-hippocampal and LC-hippocampal systems), and the specialization mechanisms of each system in different memory consolidation processes are discussed. Additionally, the anatomical and molecular foundations of D1 /D5 receptor-mediated signaling in the LC-hippocampal system are examined. Finally, the molecular mechanisms possibly underlying distinct novelty-associated memory enhancement are discussed, including the involvement of plasticity-related proteins (PRPs) in the stabilization of structural and functional changes at potentiated synapses, culminating in initial memory consolidation in the hippocampus.
KW - D/D receptor
KW - Dopamine
KW - Hippocampus
KW - Learning
KW - Locus coeruleus
KW - Long-term memory
KW - Memory consolidation
KW - Novelty
KW - Plasticity
KW - Plasticity-related proteins
KW - Synaptic plasticity
KW - Synaptic tagging and capture
KW - Ventral tegmental area
UR - http://www.scopus.com/inward/record.url?scp=85204663038&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-54864-2_14
DO - 10.1007/978-3-031-54864-2_14
M3 - Book chapter
AN - SCOPUS:85204663038
SN - 9783031548635
SP - 265
EP - 292
BT - Synaptic Tagging and Capture
A2 - Sajikumar, Sreedharan
A2 - Abel, Ted
PB - Springer International Publishing
ER -