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Understanding brain states across spacetime informed by whole-brain modelling

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  • Jakub Vohryzek, Aarhus Universitet, University of Oxford, Pompeu Fabra University
  • ,
  • Joana Cabral
  • Peter Vuust
  • Gustavo Deco, Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, ICREA, Max Planck Institute for Human Cognitive and Brain Sciences
  • ,
  • Morten L. Kringelbach

In order to survive in a complex environment, the human brain relies on the ability to flexibly adapt ongoing behaviour according to intrinsic and extrinsic signals. This capability has been linked to specific whole-brain activity patterns whose relative stability (order) allows for consistent functioning, supported by sufficient intrinsic instability needed for optimal adaptability. The emergent, spontaneous balance between order and disorder in brain activity over spacetime underpins distinct brain states. For example, depression is characterized by excessively rigid, highly ordered states, while psychedelics can bring about more disordered, sometimes overly flexible states. Recent developments in systems, computational and theoretical neuroscience have started to make inroads into the characterization of such complex dynamics over space and time. Here,we 2022 The Author(s) Published by the Royal Society. All rights reserved.

TidsskriftPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Antal sider16
StatusUdgivet - 2022

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