Ultrastructural localization of silver in rat testis and organ distribution of radioactive silver in the rat.

E Ernst; J Rungby; E Baatrup

Ultrastructural localization of silver in rat testis and organ distribution of radioactive silver in the rat.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

The deposition of silver after a single intravenous injection (2 micrograms Ag g-1 body weight) was studied in the testes of Wistar rats 24 h and 1 and 2 weeks after dosing with radiolabelled 110AgNo3 (2 micrograms Ag and 1.2 kBq g-1 body weight). Also, the temporal accumulation of silver during the experimental period was monitored in the blood, testes, epididymides, kidney, liver and brain. The subcellular distribution of silver within the testes was demonstrated by using the histochemical technique of autometallography. Silver was cleared rapidly from the blood. After an initial rise, concentrations in organs remained almost stable throughout the experimental period. Silver was especially abundant in interstitial macrophages and in the basement membrane. Deposits of silver were found in all cell types of spermatogenesis and in the lysosomes of the Sertoli cells.
Udgivelsesdato: 1991-Oct

Originalsprog	Engelsk
Tidsskrift	Journal of Applied Toxicology
Vol/bind	11
Nummer	5
Sider (fra-til)	317-21
Antal sider	4
ISSN	0260-437X
Status	Udgivet - 1992

Citationsformater

@article{cc65ed00d4a011dcabe4000ea68e967b,

title = "Ultrastructural localization of silver in rat testis and organ distribution of radioactive silver in the rat.",

abstract = "The deposition of silver after a single intravenous injection (2 micrograms Ag g-1 body weight) was studied in the testes of Wistar rats 24 h and 1 and 2 weeks after dosing with radiolabelled 110AgNo3 (2 micrograms Ag and 1.2 kBq g-1 body weight). Also, the temporal accumulation of silver during the experimental period was monitored in the blood, testes, epididymides, kidney, liver and brain. The subcellular distribution of silver within the testes was demonstrated by using the histochemical technique of autometallography. Silver was cleared rapidly from the blood. After an initial rise, concentrations in organs remained almost stable throughout the experimental period. Silver was especially abundant in interstitial macrophages and in the basement membrane. Deposits of silver were found in all cell types of spermatogenesis and in the lysosomes of the Sertoli cells. Udgivelsesdato: 1991-Oct",

keywords = "Animals, Injections, Intravenous, Male, Microscopy, Microscopy, Electron, Radioisotopes, Rats, Rats, Inbred Strains, Silver, Silver Nitrate, Testis, Tissue Distribution",

author = "E Ernst and J Rungby and E Baatrup",

year = "1992",

language = "English",

volume = "11",

pages = "317--21",

journal = "Journal of Applied Toxicology",

issn = "0260-437X",

publisher = "John Wiley and Sons Ltd",

number = "5",

}

TY - JOUR

T1 - Ultrastructural localization of silver in rat testis and organ distribution of radioactive silver in the rat.

AU - Ernst, E

AU - Rungby, J

AU - Baatrup, E

PY - 1992

Y1 - 1992

N2 - The deposition of silver after a single intravenous injection (2 micrograms Ag g-1 body weight) was studied in the testes of Wistar rats 24 h and 1 and 2 weeks after dosing with radiolabelled 110AgNo3 (2 micrograms Ag and 1.2 kBq g-1 body weight). Also, the temporal accumulation of silver during the experimental period was monitored in the blood, testes, epididymides, kidney, liver and brain. The subcellular distribution of silver within the testes was demonstrated by using the histochemical technique of autometallography. Silver was cleared rapidly from the blood. After an initial rise, concentrations in organs remained almost stable throughout the experimental period. Silver was especially abundant in interstitial macrophages and in the basement membrane. Deposits of silver were found in all cell types of spermatogenesis and in the lysosomes of the Sertoli cells. Udgivelsesdato: 1991-Oct

AB - The deposition of silver after a single intravenous injection (2 micrograms Ag g-1 body weight) was studied in the testes of Wistar rats 24 h and 1 and 2 weeks after dosing with radiolabelled 110AgNo3 (2 micrograms Ag and 1.2 kBq g-1 body weight). Also, the temporal accumulation of silver during the experimental period was monitored in the blood, testes, epididymides, kidney, liver and brain. The subcellular distribution of silver within the testes was demonstrated by using the histochemical technique of autometallography. Silver was cleared rapidly from the blood. After an initial rise, concentrations in organs remained almost stable throughout the experimental period. Silver was especially abundant in interstitial macrophages and in the basement membrane. Deposits of silver were found in all cell types of spermatogenesis and in the lysosomes of the Sertoli cells. Udgivelsesdato: 1991-Oct

KW - Animals

KW - Injections, Intravenous

KW - Male

KW - Microscopy

KW - Microscopy, Electron

KW - Radioisotopes

KW - Rats

KW - Rats, Inbred Strains

KW - Silver

KW - Silver Nitrate

KW - Testis

KW - Tissue Distribution

M3 - Journal article

C2 - 1783735

SN - 0260-437X

VL - 11

SP - 317

EP - 321

JO - Journal of Applied Toxicology

JF - Journal of Applied Toxicology

IS - 5

ER -