Ultramicronized Palmitoylethanolamide (PEA) in spinal cord injury neuropathic pain: a randomized controlled trial

Publikation: KonferencebidragPosterForskning

  • Sven Robert Andresen
  • Jette Bing, Clinic for Spinal Cord Injuries, Hornbaek, Denmark, Danmark
  • Rikke Bod Middelhede Hansen, Danmark
  • Fin Biering-Sørensen, Clinic for Spinal Cord Injuries, Hornbaek, Denmark, Danmark
  • Inger Lauge Johansen, Spinal Cord Injury Centre of Western Denmark, Viborg, Danmark
  • Ellen Merete Hagen, The Autonomic Unit, National Hospital for Neurology and Neurosurgery, Queen Square,University College London, Storbritannien
  • Andrew Rice, Department of Surgery and Cancer, Imperial College, London, UK, Storbritannien
  • Jørgen Feldbæk Nielsen
  • Flemming Winther Bach
  • Nanna Brix Finnerup
Introduction Neuropathic pain and spasticity after spinal cord injury (SCI) represent significant problems. Palmitoylethanolamide (PEA) is a fatty acid that isproduced in many cells in the body, and it is thought to potentiate endocannabinoids. PEA is suggested to reduce pain and inflammation but RCT arelacking. Normast is a medical supplement which contains PEA approved for use in Denmark. The primary aim was to investigate the effect of Normaston neuropathic pain, and secondary to study the effect of Normast on spasticity and psychological functioning in patients with spinal cord injury.Methods A randomized, double-blind, placebo-controlled parallel multicenter study. Study population of at least 66 patients must complete the 12 week trial.Questionnaires regarding neuropathic pain, spasticity, insomnia, anxiety and depression are completed before and after treatment. A numeric ratingscale for pain intensity (0-10 point) is used to measure primary outcome.Results Presently, 66 of 68 patients (74% male) have completed the trial. Of those included, 5% have complete tetraplegia, 39% incomplete tetraplegia,29% complete paraplegia and 27% incomplete paraplegia. Average age at inclusion is 55.3 (±9.5) years and average time since injury is 8.8 (±8.9)years. Causes of injury are 31% transport, 27% fall, 21% non-traumatic SCI, 14% other traumatic cause and 7% sports injuries. No major side effectshave been reported. Further results will be presented at the meeting
Udgivelsesår9 sep. 2015
Antal sider1
StatusUdgivet - 9 sep. 2015

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