Two endogenous retroviral loci appear to contribute to Multiple Sclerosis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

DOI

  • Bjørn A Nexø
  • Sara B Jensen, Department of Biomedicine, Aarhus University, The Bartholin Building, Wilhelm Meyers Allé 4, DK-8000 Aarhus C, Denmark; Laboratory for Epigenetics and Environment, Centre National de Génotypage, CEA - Institut de Génomique, 2 rue Gaston Crémieux, 91000 Evry, France.
  • ,
  • Kari K Nissen
  • Bettina Hansen
  • Magdalena J Laska

BACKGROUND: Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).

RESULTS: The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.

CONCLUSION: We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.

OriginalsprogEngelsk
TidsskriftBMC Neurology
Vol/bind16
Sider (fra-til)57
ISSN1471-2377
DOI
StatusUdgivet - 30 apr. 2016
Eksternt udgivetJa

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