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Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity

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DOI

Lasso peptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) produced by microorganisms. Here we show that the two natural products triculamin and alboverticillin, originally isolated in 1967 and 1958, respectively, with potent and specific activity against mycobacteria are in fact the same lasso peptide. We solved the structure using 2D NMR spectroscopy and expanded on the previously reported bioactivity. Through genome sequencing, we identify the responsible biosynthetic gene clusters, which curiously revealed that, unlike any known lasso peptides, their precursor peptides appear to have a follower instead of a leader peptide.

OriginalsprogEngelsk
TidsskriftJournal of Natural Products
Vol/bind85
Nummer6
Sider (fra-til)1514-1521
Antal sider8
ISSN0163-3864
DOI
StatusUdgivet - jun. 2022

Bibliografisk note

Funding Information:
T.T. acknowledge support from the Carlsberg Foundation (CF17-0854) and the Villum Fonden (23223). In addition, access to instruments at the Danish Center for Ultrahigh-Field NMR Spectroscopy funded by the Danish Ministry of Higher Education and Science (AU-2010-612-181) is acknowledged.

Publisher Copyright:
© 2022 American Chemical Society and American Society of Pharmacognosy.

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