Trefoil factors in inflammatory bowel disease

TY - JOUR

T1 - Trefoil factors in inflammatory bowel disease

AU - Aamann, Luise

AU - Vestergaard, Else Marie

AU - Grønbæk, Henning

PY - 2014

Y1 - 2014

N2 - Inflammatory bowel disease (IBD), which comprises ulcerative colitis and Crohn's disease, is characterized by inflammation of the gastrointestinal tract. The trefoil factors 1, 2, and 3 (TFF1-3) are a family of peptides that play important roles in the protection and repair of epithelial surfaces, including the gastrointestinal tract. TFFs may be involved in IBD pathogenesis and are a potential treatment option. In the present review, we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression, possible function and pharmacological role in IBD.

AB - Inflammatory bowel disease (IBD), which comprises ulcerative colitis and Crohn's disease, is characterized by inflammation of the gastrointestinal tract. The trefoil factors 1, 2, and 3 (TFF1-3) are a family of peptides that play important roles in the protection and repair of epithelial surfaces, including the gastrointestinal tract. TFFs may be involved in IBD pathogenesis and are a potential treatment option. In the present review, we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression, possible function and pharmacological role in IBD.

U2 - 10.3748/wjg.v20.i12.3223

DO - 10.3748/wjg.v20.i12.3223

M3 - Review

C2 - 24696606

SN - 1007-9327

VL - 20

SP - 3223

EP - 3230

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

IS - 12

ER -