Transport unplugged: KCCs are regulated through an N-terminal plug of the ion pathway

Rasmus Kock Flygaard, Caroline Neumann, Joseph Anthony Lyons, Poul Nissen*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisKommentar/debat/letter to the editorForskningpeer review

Abstract

The ability to regulate transmembrane ion transport in response to various cues is vital to any living cell. In neurons, one key example of critical ion control relates to the extrusion of chloride mediated by the potassium-chloride-cotransporters (KCC1-4). In a recent hallmark study, Chi et␣al (2021) report cryo-EM structures of human KCC1 and KCC3b, delineating in detail how regulation by phosphorylation inhibits the transport activity. The authors also identify a stabilizing binding site for nucleotides and speculate on its functional role.

OriginalsprogEngelsk
Artikelnummere108371
TidsskriftEMBO Journal
Vol/bind40
Nummer14
Antal sider3
ISSN0261-4189
DOI
StatusUdgivet - jul. 2021

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