Transport unplugged:: KCCs are regulated through an N-terminal plug of the ion pathway

Rasmus Kock Flygaard; Caroline Neumann; Joseph Anthony Lyons; Poul Nissen

doi:10.15252/embj.2021108371

Transport unplugged: KCCs are regulated through an N-terminal plug of the ion pathway

Rasmus Kock Flygaard, Caroline Neumann, Joseph Anthony Lyons, Poul Nissen^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Kommentar/debat/letter to the editor › Forskning › peer review

2 Citationer (Scopus)

Abstract

The ability to regulate transmembrane ion transport in response to various cues is vital to any living cell. In neurons, one key example of critical ion control relates to the extrusion of chloride mediated by the potassium-chloride-cotransporters (KCC1-4). In a recent hallmark study, Chi et␣al (2021) report cryo-EM structures of human KCC1 and KCC3b, delineating in detail how regulation by phosphorylation inhibits the transport activity. The authors also identify a stabilizing binding site for nucleotides and speculate on its functional role.

Originalsprog	Engelsk
Artikelnummer	e108371
Tidsskrift	EMBO Journal
Vol/bind	40
Nummer	14
Antal sider	3
ISSN	0261-4189
DOI	https://doi.org/10.15252/embj.2021108371
Status	Udgivet - jul. 2021

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title = "Transport unplugged:: KCCs are regulated through an N-terminal plug of the ion pathway",

abstract = "The ability to regulate transmembrane ion transport in response to various cues is vital to any living cell. In neurons, one key example of critical ion control relates to the extrusion of chloride mediated by the potassium-chloride-cotransporters (KCC1-4). In a recent hallmark study, Chi et␣al (2021) report cryo-EM structures of human KCC1 and KCC3b, delineating in detail how regulation by phosphorylation inhibits the transport activity. The authors also identify a stabilizing binding site for nucleotides and speculate on its functional role.",

keywords = "Binding Sites, Chlorides/metabolism, Humans, Phosphorylation, Protein Domains, Symporters/genetics",

author = "{Kock Flygaard}, Rasmus and Caroline Neumann and {Anthony Lyons}, Joseph and Poul Nissen",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = jul,

doi = "10.15252/embj.2021108371",

language = "English",

volume = "40",

journal = "EMBO Journal",

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T1 - Transport unplugged:

T2 - KCCs are regulated through an N-terminal plug of the ion pathway

AU - Kock Flygaard, Rasmus

AU - Neumann, Caroline

AU - Anthony Lyons, Joseph

AU - Nissen, Poul

PY - 2021/7

Y1 - 2021/7

N2 - The ability to regulate transmembrane ion transport in response to various cues is vital to any living cell. In neurons, one key example of critical ion control relates to the extrusion of chloride mediated by the potassium-chloride-cotransporters (KCC1-4). In a recent hallmark study, Chi et␣al (2021) report cryo-EM structures of human KCC1 and KCC3b, delineating in detail how regulation by phosphorylation inhibits the transport activity. The authors also identify a stabilizing binding site for nucleotides and speculate on its functional role.

AB - The ability to regulate transmembrane ion transport in response to various cues is vital to any living cell. In neurons, one key example of critical ion control relates to the extrusion of chloride mediated by the potassium-chloride-cotransporters (KCC1-4). In a recent hallmark study, Chi et␣al (2021) report cryo-EM structures of human KCC1 and KCC3b, delineating in detail how regulation by phosphorylation inhibits the transport activity. The authors also identify a stabilizing binding site for nucleotides and speculate on its functional role.

KW - Binding Sites

KW - Chlorides/metabolism

KW - Humans

KW - Phosphorylation

KW - Protein Domains

KW - Symporters/genetics

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U2 - 10.15252/embj.2021108371

DO - 10.15252/embj.2021108371

M3 - Comment/debate/letter to the editor

C2 - 34031898

AN - SCOPUS:85106217134

SN - 0261-4189

VL - 40

JO - EMBO Journal

JF - EMBO Journal

IS - 14

M1 - e108371

ER -

Transport unplugged: KCCs are regulated through an N-terminal plug of the ion pathway

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