The choroid plexus is a small but very active epithelial structure located in the brain ventricles. Here, it secretes the majority of the cerebrospinal fluid that covers the brain and spinal cord. The epithelial cells of the choroid plexus have a high rate of fluid secretion and differs from many other secretory epithelia in the organization of the main ion transporters. One striking difference is the apical localization of the Na,K ATPase. In recent years focus has increased on the role of the ion transporters as more studies have indicated implication of increased transport in disorders such as hydrocephalus, idiopathic intracranial hypertension and sequelae following intraventricular hemorrhages. The role of the choroid plexus ion transporters in regulation of composition of the cerebrospinal fluid has also been the focus in research in recent years as a regulator of breathing, blood pressure and heart rate.
This chapter focuses on the role of key ion transporters involved in cerebrospinal fluid secretion and cerebrospinal fluid ion composition. The chapter gives an overview of established factors as well as controversies in the area of ion transporters and finally discusses the future perspectives related to targeting treatment of cerebrospinal fluid disorders toward transporters on the choroid plexus epithelium.
|Cerebrospinal fluid and subarachnoid space : Clinical Anatomy and Physiology: Volume 1
|R. Shane Tubbs
|Udgivet - okt. 2022