Transmuscular quadratus lumborum block for total laparoscopic hysterectomy: A double-blind, randomized, placebo-controlled trial

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Standard

Transmuscular quadratus lumborum block for total laparoscopic hysterectomy : A double-blind, randomized, placebo-controlled trial. / Hansen, Christian; Dam, Mette; Nielsen, Martin Vedel; Tanggaard, Katrine B.; Poulsen, Troels DIrch; Bendtsen, Thomas Fichtner; Børglum, Jens.

I: Regional Anesthesia and Pain Medicine, Bind 46, Nr. 1, 01.2021, s. 25-30.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Hansen, C, Dam, M, Nielsen, MV, Tanggaard, KB, Poulsen, TDI, Bendtsen, TF & Børglum, J 2021, 'Transmuscular quadratus lumborum block for total laparoscopic hysterectomy: A double-blind, randomized, placebo-controlled trial', Regional Anesthesia and Pain Medicine, bind 46, nr. 1, s. 25-30. https://doi.org/10.1136/rapm-2020-101931

APA

Hansen, C., Dam, M., Nielsen, M. V., Tanggaard, K. B., Poulsen, T. DI., Bendtsen, T. F., & Børglum, J. (2021). Transmuscular quadratus lumborum block for total laparoscopic hysterectomy: A double-blind, randomized, placebo-controlled trial. Regional Anesthesia and Pain Medicine, 46(1), 25-30. https://doi.org/10.1136/rapm-2020-101931

CBE

Hansen C, Dam M, Nielsen MV, Tanggaard KB, Poulsen TDI, Bendtsen TF, Børglum J. 2021. Transmuscular quadratus lumborum block for total laparoscopic hysterectomy: A double-blind, randomized, placebo-controlled trial. Regional Anesthesia and Pain Medicine. 46(1):25-30. https://doi.org/10.1136/rapm-2020-101931

MLA

Vancouver

Hansen C, Dam M, Nielsen MV, Tanggaard KB, Poulsen TDI, Bendtsen TF o.a. Transmuscular quadratus lumborum block for total laparoscopic hysterectomy: A double-blind, randomized, placebo-controlled trial. Regional Anesthesia and Pain Medicine. 2021 jan;46(1):25-30. https://doi.org/10.1136/rapm-2020-101931

Author

Hansen, Christian ; Dam, Mette ; Nielsen, Martin Vedel ; Tanggaard, Katrine B. ; Poulsen, Troels DIrch ; Bendtsen, Thomas Fichtner ; Børglum, Jens. / Transmuscular quadratus lumborum block for total laparoscopic hysterectomy : A double-blind, randomized, placebo-controlled trial. I: Regional Anesthesia and Pain Medicine. 2021 ; Bind 46, Nr. 1. s. 25-30.

Bibtex

@article{2e4ef2c7ef194d4881af1301ad5e46d0,
title = "Transmuscular quadratus lumborum block for total laparoscopic hysterectomy: A double-blind, randomized, placebo-controlled trial",
abstract = "Background The population of patients scheduled for total laparoscopic hysterectomy at our surgical center is heterogeneous concerning a multitude of demographic variables such as age, collateral surgery and malign or benign pathogenesis. A common denominator is moderate to severe postoperative pain and a substantial opioid consumption. A recent procedure specific postoperative pain management (PROSPECT) review found no gain from the regional techniques included. The transmuscular quadratus lumborum (TQL) block has shown promising results in recent trials for other types of surgery. The aim of the current study was to investigate the analgesic efficacy of the ultrasound-guided TQL block for total laparoscopic hysterectomy. Methods We enrolled 70 patients and randomly allocated participants to preoperative bilateral ultrasound-guided TQL block with either 60 mL 0.375% ropivacaine or 60 mL isotonic saline. Preoperatively, all patients received the TQL block (active or placebo) as well as a standardized multimodal analgesic regimen consisting of oral paracetamol, ibuprofen and dexamethasone. Intraoperatively, intravenous sufentanil 0.2 μg/kg was administered 30 min prior to emergence. Primary outcome Opioid consumption during the first 12 postoperative hours. Secondary outcomes Pain scores, times to first opioid demand and first ambulation, nausea and vomiting, and total opioid consumption during the first 24 postoperative hours. Results No significant intergroup differences were observed for any outcome. Mean (SD) oral morphine equivalent consumption the first 12 postoperative hours was 58.4 mg (48.3) vs 62.9 mg (48.5), p=0.70, for group ropivacaine versus group saline. Conclusion Preoperative bilateral ultrasound-guided TQL block did not reduce opioid consumption after total laparoscopic hysterectomy. Trial registration numbers NCT 03650998, EudraCT (2017-004593-34). ",
keywords = "anesthesia, local, pain management, ultrasonography",
author = "Christian Hansen and Mette Dam and Nielsen, {Martin Vedel} and Tanggaard, {Katrine B.} and Poulsen, {Troels DIrch} and Bendtsen, {Thomas Fichtner} and Jens B{\o}rglum",
note = "Publisher Copyright: {\textcopyright} 2021 BMJ Publishing Group. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
doi = "10.1136/rapm-2020-101931",
language = "English",
volume = "46",
pages = "25--30",
journal = "Regional Anesthesia and Pain Medicine",
issn = "1098-7339",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "1",

}

RIS

TY - JOUR

T1 - Transmuscular quadratus lumborum block for total laparoscopic hysterectomy

T2 - A double-blind, randomized, placebo-controlled trial

AU - Hansen, Christian

AU - Dam, Mette

AU - Nielsen, Martin Vedel

AU - Tanggaard, Katrine B.

AU - Poulsen, Troels DIrch

AU - Bendtsen, Thomas Fichtner

AU - Børglum, Jens

N1 - Publisher Copyright: © 2021 BMJ Publishing Group. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2021/1

Y1 - 2021/1

N2 - Background The population of patients scheduled for total laparoscopic hysterectomy at our surgical center is heterogeneous concerning a multitude of demographic variables such as age, collateral surgery and malign or benign pathogenesis. A common denominator is moderate to severe postoperative pain and a substantial opioid consumption. A recent procedure specific postoperative pain management (PROSPECT) review found no gain from the regional techniques included. The transmuscular quadratus lumborum (TQL) block has shown promising results in recent trials for other types of surgery. The aim of the current study was to investigate the analgesic efficacy of the ultrasound-guided TQL block for total laparoscopic hysterectomy. Methods We enrolled 70 patients and randomly allocated participants to preoperative bilateral ultrasound-guided TQL block with either 60 mL 0.375% ropivacaine or 60 mL isotonic saline. Preoperatively, all patients received the TQL block (active or placebo) as well as a standardized multimodal analgesic regimen consisting of oral paracetamol, ibuprofen and dexamethasone. Intraoperatively, intravenous sufentanil 0.2 μg/kg was administered 30 min prior to emergence. Primary outcome Opioid consumption during the first 12 postoperative hours. Secondary outcomes Pain scores, times to first opioid demand and first ambulation, nausea and vomiting, and total opioid consumption during the first 24 postoperative hours. Results No significant intergroup differences were observed for any outcome. Mean (SD) oral morphine equivalent consumption the first 12 postoperative hours was 58.4 mg (48.3) vs 62.9 mg (48.5), p=0.70, for group ropivacaine versus group saline. Conclusion Preoperative bilateral ultrasound-guided TQL block did not reduce opioid consumption after total laparoscopic hysterectomy. Trial registration numbers NCT 03650998, EudraCT (2017-004593-34).

AB - Background The population of patients scheduled for total laparoscopic hysterectomy at our surgical center is heterogeneous concerning a multitude of demographic variables such as age, collateral surgery and malign or benign pathogenesis. A common denominator is moderate to severe postoperative pain and a substantial opioid consumption. A recent procedure specific postoperative pain management (PROSPECT) review found no gain from the regional techniques included. The transmuscular quadratus lumborum (TQL) block has shown promising results in recent trials for other types of surgery. The aim of the current study was to investigate the analgesic efficacy of the ultrasound-guided TQL block for total laparoscopic hysterectomy. Methods We enrolled 70 patients and randomly allocated participants to preoperative bilateral ultrasound-guided TQL block with either 60 mL 0.375% ropivacaine or 60 mL isotonic saline. Preoperatively, all patients received the TQL block (active or placebo) as well as a standardized multimodal analgesic regimen consisting of oral paracetamol, ibuprofen and dexamethasone. Intraoperatively, intravenous sufentanil 0.2 μg/kg was administered 30 min prior to emergence. Primary outcome Opioid consumption during the first 12 postoperative hours. Secondary outcomes Pain scores, times to first opioid demand and first ambulation, nausea and vomiting, and total opioid consumption during the first 24 postoperative hours. Results No significant intergroup differences were observed for any outcome. Mean (SD) oral morphine equivalent consumption the first 12 postoperative hours was 58.4 mg (48.3) vs 62.9 mg (48.5), p=0.70, for group ropivacaine versus group saline. Conclusion Preoperative bilateral ultrasound-guided TQL block did not reduce opioid consumption after total laparoscopic hysterectomy. Trial registration numbers NCT 03650998, EudraCT (2017-004593-34).

KW - anesthesia

KW - local

KW - pain management

KW - ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=85094208958&partnerID=8YFLogxK

U2 - 10.1136/rapm-2020-101931

DO - 10.1136/rapm-2020-101931

M3 - Journal article

C2 - 33082286

AN - SCOPUS:85094208958

VL - 46

SP - 25

EP - 30

JO - Regional Anesthesia and Pain Medicine

JF - Regional Anesthesia and Pain Medicine

SN - 1098-7339

IS - 1

ER -