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Translational repression of E2F1 mRNA in carcinoma in situ and normal testis correlates with expression of the miR-17-92 cluster

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  • Guy Wayne Novotny, Department of Growth & Reproduction, Rigshospitalet, Danmark
  • Stine Sonne, Department of Growth & Reproduction, Rigshospitalet, Danmark
  • Jens Erik Nielsen, Danmark
  • Søren Peter Jonstrup, Danmark
  • Martin Andreas Hansen, Danmark
  • N E Skakkebaek, Department of Growth & Reproduction, Rigshospitalet, Danmark
  • Ewa Rajpert-De Meyts, Department of Growth & Reproduction, Rigshospitalet, Danmark
  • Jørgen Kjems
  • H Leffers, Danmark
The E2F1 transcription factor is a key regulatory factor of both apoptosis and cell cycle progression, and depending on cellular context, can act as either an oncogene or a tumour suppressor. Consequently, gene mutations that lead to deregulation of E2F1 activity are detected in a majority of human cancers.1 Recently, an array study identified E2F1 as upregulated in human testis containing preinvasive carcinoma in situ (CIS) cells when compared with normal human testis.2 Apparently, supporting this, an E2F1 overexpressing mouse demonstrated generation of CIS-like cells in testis that were otherwise atrophying owing to massive E2F1-induced apoptosis of germ cells
OriginalsprogEngelsk
TidsskriftCell Death and Differentiation
Vol/bind14
Nummer4
Sider (fra-til)879-882
Antal sider4
ISSN1350-9047
DOI
StatusUdgivet - 2007

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