Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

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DOI

  • David V Conti, University of Southern California/Norris Comprehensive Cancer Center
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  • Burcu F Darst, University of Southern California/Norris Comprehensive Cancer Center
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  • Lilit C Moss, University of Southern California/Norris Comprehensive Cancer Center
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  • Edward J Saunders, The Royal Marsden / The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre, London, UK.
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  • Xin Sheng, University of Southern California/Norris Comprehensive Cancer Center
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  • Alisha Chou, University of Southern California/Norris Comprehensive Cancer Center
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  • Fredrick R Schumacher, Case Western Reserve Univ, Case Western Reserve University, Dept Astron
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  • Ali Amin Al Olama, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom;
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  • Sara Benlloch, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom;
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  • Tokhir Dadaev, The Royal Marsden / The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre, London, UK.
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  • Mark N Brook, The Royal Marsden / The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre, London, UK.
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  • Ali Sahimi, University of Southern California/Norris Comprehensive Cancer Center
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  • Thomas J Hoffmann, Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, Pennsylvania 19104 and Department of Medical Epidemiology and Biostatistics and Department of Public Health Sciences, Karolinska Institute, SE 171-77 Stockholm, Sweden., Department of Dermatology, University of California, San Diego, California; Department of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego, California., University of California San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA., St. Mary's College of CA Moraga, CA, US, Institute for Human Genetics
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  • Atushi Takahashi, Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
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  • Koichi Matsuda, The University of Tokyo
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  • Yukihide Momozawa, Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
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  • Masashi Fujita, Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
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  • Kenneth Muir, Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK.
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  • Artitaya Lophatananon, Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK.
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  • Peggy Wan, University of Southern California/Norris Comprehensive Cancer Center
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  • Loic Le Marchand, University of Hawaii Cancer Center, Honolulu, Hawaii.
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  • Lynne R Wilkens, University of Hawaii Cancer Center, Honolulu, Hawaii.
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  • Victoria L Stevens, Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
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  • Susan M Gapstur, Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
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  • Brian D Carter, Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
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  • Johanna Schleutker, Department of Medical Physics, Turku PET Centre, Turku University Central Hospital and University of Turku, Turku
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  • Teuvo L J Tammela, Faculty of Medicine and Health Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.
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  • Csilla Sipeky, Department of Medical Physics, Turku PET Centre, Turku University Central Hospital and University of Turku, Turku
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  • Anssi Auvinen, Tampere University Hospital and University of Tampere, Tampere, Finland.
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  • Graham G Giles, Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
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  • Melissa C Southey, Monash Med Ctr, Monash University, Monash Heart
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  • Robert J MacInnis, Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
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  • Cezary Cybulski, Pomeranian Med Univ, Pomeranian Medical University
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  • Dominika Wokołorczyk, Pomeranian Med Univ, Pomeranian Medical University
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  • Jan Lubiński, Pomeranian Med Univ, Pomeranian Medical University
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  • David E Neal, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom; Department of Physics, University of Oxford, Oxford, United Kingdom; University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
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  • Jenny L Donovan, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
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  • Freddie C Hamdy, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom; Department of Physics, University of Oxford, Oxford, United Kingdom; University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
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  • Richard M Martin, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
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  • Børge G Nordestgaard, 1Copenhagen University Hospital, Copenhagen, Denmark. 2Aarhus University Hospital, Aarhus, Denmark. 3University of Copenhagen, Copenhagen, Denmark. 4Odense University Hospital, Odense, Denmark.
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  • Sune F Nielsen, Københavns Universitet - Graduate School of Health and Medical Sciences Faculty of Health and Medical Sciences, 1Copenhagen University Hospital, Copenhagen, Denmark. 2Aarhus University Hospital, Aarhus, Denmark. 3University of Copenhagen, Copenhagen, Denmark. 4Odense University Hospital, Odense, Denmark., From the Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital (A.D.K., S.E.B., B.G.N.), Faculty of Health and Medical Sciences (A.D.K., J.S.J., S.E.B., B.G.N.), The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital (A.D.K., S.E.B., B.G.N.), Department of Medicine and Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital (J.S.J.), and The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhage
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  • Maren Weischer, 1Copenhagen University Hospital, Copenhagen, Denmark. 2Aarhus University Hospital, Aarhus, Denmark. 3University of Copenhagen, Copenhagen, Denmark. 4Odense University Hospital, Odense, Denmark.
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  • Stig E Bojesen, 1Copenhagen University Hospital, Copenhagen, Denmark. 2Aarhus University Hospital, Aarhus, Denmark. 3University of Copenhagen, Copenhagen, Denmark. 4Odense University Hospital, Odense, Denmark.
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  • Martin Andreas Røder, 1Copenhagen University Hospital, Copenhagen, Denmark. 2Aarhus University Hospital, Aarhus, Denmark. 3University of Copenhagen, Copenhagen, Denmark. 4Odense University Hospital, Odense, Denmark.
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  • Peter Iversen, Copenhagen Prostate Cancer Center
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  • Jyotsna Batra, Queensland University of technology,
  • Suzanne Chambers, Software Technology Group, Darmstadt University of Technology
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  • Leire Moya, Queensland University of technology,
  • Lisa Horvath, Chris O'Brien Lifehouse (COBLH)
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  • Judith A Clements, Queensland University of technology,
  • Wayne Tilley, Univ Adelaide, University of Adelaide, Dept Hist
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  • Gail P Risbridger, Monash Med Ctr, Monash University, Monash Heart
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  • Henrik Gronberg, Karolinska University Hospital og Karolinska Institute
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  • Markus Aly, Karolinska University Hospital og Karolinska Institute
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  • Robert Szulkin, Karolinska University Hospital og Karolinska Institute
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  • Martin Eklund, Karolinska University Hospital og Karolinska Institute
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  • Tobias Nordström, Karolinska University Hospital og Karolinska Institute
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  • Nora Pashayan, Univ Coll London Hosp NHS Fdn Trust, University College London Hospitals NHS Foundation Trust, University of London, University College London, Inst Nucl Med
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  • Alison M Dunning, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom;
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  • Maya Ghoussaini, Sanger Inst, Wellcome Trust Sanger Institute
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  • Ruth C Travis, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom; Department of Physics, University of Oxford, Oxford, United Kingdom; University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
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  • Tim J Key, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom; Department of Physics, University of Oxford, Oxford, United Kingdom; University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
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  • Elio Riboli, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit
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  • Jong Y Park, Moffitt Cancer Center
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  • Thomas A Sellers, Moffitt Cancer Center
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  • Hui-Yi Lin, Louisiana State University Health Sciences Center
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  • Demetrius Albanes, National Institute of Health's National Cancer Institute: Quantitative Imaging Network
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  • Stephanie J Weinstein, National Institute of Health's National Cancer Institute: Quantitative Imaging Network
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  • Lorelei A Mucci, Harvard TH Chan Sch Publ Hlth, Harvard T.H. Chan School of Public Health
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  • Edward Giovannucci, Harvard TH Chan Sch Publ Hlth, Harvard T.H. Chan School of Public Health
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  • Sara Lindstrom, Univ Washington, University of Washington, University of Washington Seattle, University of Washington Tacoma, Dept Biol Oceanog
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  • Peter Kraft, Harvard TH Chan Sch Publ Hlth, Harvard T.H. Chan School of Public Health
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  • David J Hunter, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom; Department of Physics, University of Oxford, Oxford, United Kingdom; University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
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  • Kathryn L Penney, Harvard Medical School / Brigham and Women's Hospital
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  • Constance Turman, Harvard TH Chan Sch Publ Hlth, Harvard T.H. Chan School of Public Health
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  • Catherine M Tangen, SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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  • Phyllis J Goodman, SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington.
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  • Ian M Thompson, CHRISTUS Santa Rosa Hospital-Medical Center, San Antonio, TX, USA.
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  • Robert J Hamilton, Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto Western Hosp, University of Toronto, University Health Network Toronto, Ontario Institute for Cancer Research and Cancer Care Ontario, Department of Surgery, Urology Clinic, University of Verona, Verona, Italy.
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  • Neil E Fleshner, Department of Surgical Oncology
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  • Antonio Finelli, Division of Paediatric Urology, Clinic of Urology, University of Erlangen-Nürnberg, Erlangen, Germany.
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  • Marie-Élise Parent, Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.
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  • Janet L Stanford, Fred Hutchinson Cancer Research Center
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  • Elaine A Ostrander, National Institute of Environmental Health Sciences, National Institutes of Health
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  • Milan S Geybels, Fred Hutchinson Cancer Research Center
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  • Stella Koutros, National Institute of Health's National Cancer Institute: Quantitative Imaging Network
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  • Laura E Beane Freeman, National Institute of Health's National Cancer Institute: Quantitative Imaging Network
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  • Meir Stampfer, Harvard Medical School / Brigham and Women's Hospital
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  • Alicja Wolk, Karolinska Univ Hosp, Karolinska Institutet, Karolinska University Hospital
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  • Niclas Håkansson, Karolinska Univ Hosp, Karolinska Institutet, Karolinska University Hospital
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  • Gerald L Andriole, The George Washington University School of Medicine, Washington, DC, USA.
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  • Robert N Hoover, National Institute of Health's National Cancer Institute: Quantitative Imaging Network
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  • Mitchell J Machiela, National Institute of Health's National Cancer Institute: Quantitative Imaging Network
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  • Karina Dalsgaard Sørensen
  • Michael Borre
  • William J Blot, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
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  • Wei Zheng, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
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  • Edward D Yeboah, Department of Child Health, University of Ghana Medical School, Korle Bu Teaching Hospital, Accra, Ghana. lornarenner@gmail.com
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  • James E Mensah, Department of Child Health, University of Ghana Medical School, Korle Bu Teaching Hospital, Accra, Ghana. lornarenner@gmail.com
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  • Yong-Jie Lu, Queen Mary Univ London, Queen Mary University London, University of London, Barts & London Sch Med & Denistry
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  • Hong-Wei Zhang, Second Military Medical University, Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China; Shanghai Med-X Engineering Research Center, Shanghai Jiao Tong University, Shanghai, China.
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  • Ninghan Feng, Nanjing Medical University, Nanjing, China
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  • Xueying Mao, Queen Mary Univ London, Queen Mary University London, University of London, Barts & London Sch Med & Denistry
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  • Yudong Wu, Zhengzhou Univ, Zhengzhou University, Coll Chem & Mol Engn
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  • Shan-Chao Zhao, Southern Medical University
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  • Zan Sun, The Emergency & Critical Care Center of Beijing Anzhen Hospital, Capital Medical University, Beijing, the People's Republic of China.
  • ,
  • Stephen N Thibodeau, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, NY
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  • Shannon K McDonnell, Mayo Clinic, Department of Health Sciences, Division of Biomedical Statistics and Informatics, Rochester, Minnesota, United States of America.
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  • Daniel J Schaid, Mayo Clinic, Department of Health Sciences, Division of Biomedical Statistics and Informatics, Rochester, Minnesota, United States of America.
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  • Catharine M L West, Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK.
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  • Neil Burnet, Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK.
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  • Gill Barnett, Department of Oncology, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB1 8RN, UK.
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  • Christiane Maier, Humangenetik Tuebingen
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  • Thomas Schnoeller, From the Danish Multiple Sclerosis Center (M.D.B., T.A.C., F.S., P.S.S., M.M.), Rigshospitalet; Copenhagen University Hospital Rigshospitalet (J.F., H.H.-K.-R.), Glostrup; Slagelse Hospital (M.K.G.); Odense University Hospital (Z.I., T.S.), University of Southern Denmark; Hospital of Southern Jutland (M.K.), Sønderborg; Aalborg University Hospital (Z.M.); Aarhus University Hospital (T.P., P.V.R.); Greater Copenhagen Hospitals-NOH (H.R.), Hillerød; University Hospital of Sjaelland (A.T.), Roskilde; and Depar
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  • Manuel Luedeke, genetikum
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  • Adam S Kibel, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA
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  • Bettina F Drake, The George Washington University School of Medicine, Washington, DC, USA.
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  • Olivier Cussenot, Tenon Hospital
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  • Géraldine Cancel-Tassin, Tenon Hospital
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  • Florence Menegaux, University Paris-Saclay, University Paris-Sud, Villejuif
  • ,
  • Thérèse Truong, University Paris-Saclay, University Paris-Sud, Villejuif
  • ,
  • Yves Akoli Koudou, University Paris-Saclay, University Paris-Sud, Villejuif
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  • Esther M John, Cardiovascular Institute, Stanford University, School of Medicine, Stanford, CA, USA.
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  • Eli Marie Grindedal, Department of Gynaecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. Institute for Cancer Genetics and Informatics, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. Faculty of Medicine, University of Oslo, Oslo, Norway.
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  • Lovise Maehle, Department of Gynaecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. Institute for Cancer Genetics and Informatics, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. Faculty of Medicine, University of Oslo, Oslo, Norway.
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  • Kay-Tee Khaw, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom;
  • ,
  • Sue A Ingles, University of Southern California/Norris Comprehensive Cancer Center
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  • Mariana C Stern, University of Southern California/Norris Comprehensive Cancer Center
  • ,
  • Ana Vega, Fundación Pública Galega de Medicina Xenómica
  • ,
  • Antonio Gómez-Caamaño, Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
  • ,
  • Laura Fachal, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom;
  • ,
  • Barry S Rosenstein, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of
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  • Sarah L Kerns, University of Rochester Medical Center, Rochester, NY, USA
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  • Harry Ostrer, Albert Einstein Coll Med, Yeshiva University, Albert Einstein College of Medicine, Dept Psychiat & Behav Sci
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  • Manuel R Teixeira, Portuguese Oncology Institute of Porto (IPO Porto)
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  • Paula Paulo, Portuguese Oncology Institute of Porto (IPO Porto)
  • ,
  • Andreia Brandão, Portuguese Oncology Institute of Porto (IPO Porto)
  • ,
  • Stephen Watya, Uro Care
  • ,
  • Alexander Lubwama, Uro Care
  • ,
  • Jeannette T Bensen, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
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  • Elizabeth T H Fontham, National Institute of Health's National Cancer Institute: Quantitative Imaging Network
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  • James Mohler, Univ North Carolina Chapel Hill, University of North Carolina, University of North Carolina Chapel Hill, University of North Carolina School of Medicine, Dept Phys & Astron
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  • Jack A Taylor, National Institute of Environmental Health Sciences, National Institutes of Health
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  • Manolis Kogevinas, ISGlobal, ISGlobal
  • ,
  • Javier Llorca, CIBER Epidemiologia y Salud Publica (CIBERESP).
  • ,
  • Gemma Castaño-Vinyals, ISGlobal, ISGlobal
  • ,
  • Lisa Cannon-Albright, University of Utah School of Medicine, Salt Lake City, Utah; Utah Center for Advanced Imaging Research, Salt Lake City, Utah.
  • ,
  • Craig C Teerlink, University of Utah School of Medicine, Salt Lake City, Utah; Utah Center for Advanced Imaging Research, Salt Lake City, Utah.
  • ,
  • Chad D Huff, The Texas University, MD Anderson Cancer Center, Pathology
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  • Sara S Strom, The Texas University, MD Anderson Cancer Center, Pathology
  • ,
  • Luc Multigner, CHU Rennes, Rennes 1 University, Rennes, France.
  • ,
  • Pascal Blanchet, CHU Rennes, Rennes 1 University, Rennes, France.
  • ,
  • Laurent Brureau, CHU Rennes, Rennes 1 University, Rennes, France.
  • ,
  • Radka Kaneva, Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, 1504, Bulgaria.
  • ,
  • Chavdar Slavov, Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, 1504, Bulgaria.
  • ,
  • Vanio Mitev, Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, 1504, Bulgaria.
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  • Robin J Leach, University of Texas Health Science Center, San Antonio, Texas, USA.
  • ,
  • Brandi Weaver, University of Texas Health Science Center, San Antonio, Texas, USA.
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  • Hermann Brenner, German Cancer Research Center (DKFZ)
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  • Katarina Cuk, German Cancer Research Center (DKFZ)
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  • Bernd Holleczek, Saarland Cancer Registry, Saarbrücken, Germany.
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  • Kai-Uwe Saum, German Cancer Research Center (DKFZ)
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  • Eric A Klein, Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • ,
  • Ann W Hsing, Cardiovascular Institute, Stanford University, School of Medicine, Stanford, CA, USA.
  • ,
  • Rick A Kittles, Division of Health Equities
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  • Adam B Murphy, Northwestern Univ, Northwestern University, PTHMS
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  • Christopher J Logothetis, The Texas University, MD Anderson Cancer Center, Pathology
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  • Jeri Kim, The Texas University, MD Anderson Cancer Center, Pathology
  • ,
  • Susan L Neuhausen, Beckman Research Institute of the City of Hope
  • ,
  • Linda Steele, Beckman Research Institute of the City of Hope
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  • Yuan Chun Ding, Beckman Research Institute of the City of Hope
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  • William B Isaacs, Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA.
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  • Barbara Nemesure, Division of Cardiology, Stony Brook University, Stony Brook, New York.
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  • Anselm J M Hennis, Division of Cardiology, Stony Brook University, Stony Brook, New York.
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  • John Carpten, University of Southern California / Norris Cancer Center, University of Southern California, Los Angeles
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  • Hardev Pandha, The University of Surrey, Guildford, Surrey, GU2 7XH, UK.
  • ,
  • Agnieszka Michael, The University of Surrey, Guildford, Surrey, GU2 7XH, UK.
  • ,
  • Kim De Ruyck, Univ Ghent, Ghent University, Ghent University, Lab Protistol & Aquat Ecol
  • ,
  • Gert De Meerleer, University Hospital Ghent and SafePedrug, Ghent University, Ghent, Belgium.
  • ,
  • Piet Ost, University Hospital Ghent and SafePedrug, Ghent University, Ghent, Belgium.
  • ,
  • Jianfeng Xu, Medicine, NorthShore University HealthSystem.
  • ,
  • Azad Razack, Julius Centre University of Malaya (JCUM), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • ,
  • Jasmine Lim, Julius Centre University of Malaya (JCUM), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
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  • Soo-Hwang Teo, Cancer Research Malaysia (CRM)
  • ,
  • Lisa F Newcomb, Univ Washington, University of Washington, University of Washington Seattle, University of Washington Tacoma, Dept Biol Oceanog
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  • Daniel W Lin, Univ Washington, University of Washington, University of Washington Seattle, University of Washington Tacoma, Dept Biol Oceanog
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  • Jay H Fowke, University of Tennessee Health Science Center
  • ,
  • Christine Neslund-Dudas, Henry Ford Hosp, Henry Ford Hospital
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  • Benjamin A Rybicki, Henry Ford Hosp, Henry Ford Hospital
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  • Marija Gamulin, School of Medicine and University Hospital Centre, University of Zagreb
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  • Davor Lessel, University Medical Center Hamburg-Eppendorf
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  • Tomislav Kulis, University Hospital Center Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia.
  • ,
  • Nawaid Usmani, Univ Alberta, University of Alberta, Dept Psychiat
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  • Sandeep Singhal, Univ Alberta, University of Alberta, Dept Psychiat
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  • Matthew Parliament, Univ Alberta, University of Alberta, Dept Psychiat
  • ,
  • Frank Claessens, Molecular Endocrinology Laboratory, Odense University Hospital
  • ,
  • Steven Joniau, Leuven Centre for Algology & Pain Management, University Hospitals Leuven, University Hospitals Leuven, Pellenberg, Belgium.
  • ,
  • Thomas Van den Broeck, Molecular Endocrinology Laboratory, Odense University Hospital
  • ,
  • Manuela Gago-Dominguez, Complejo Hospitalario Universitario de Santiago
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  • Jose Esteban Castelao, CHUVI Hospital
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  • Maria Elena Martinez, Department of Dermatology, University of California, San Diego, California; Department of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego, California.
  • ,
  • Samantha Larkin, The Hatter Cardiovascular Institute, University College London, London, UK; University Hospital Southampton National Health Service Foundation Trust, Southampton, UK.
  • ,
  • Paul A Townsend, The University of Surrey, Guildford, Surrey, GU2 7XH, UK.
  • ,
  • Claire Aukim-Hastie, The University of Surrey, Guildford, Surrey, GU2 7XH, UK.
  • ,
  • William S Bush, Case Western Reserve Univ, Case Western Reserve University, Dept Astron
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  • Melinda C Aldrich, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
  • ,
  • Dana C Crawford, Case Western Reserve Univ, Case Western Reserve University, Dept Astron
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  • Shiv Srivastava, Department of Family Medicine, Uniformed Services of Health Sciences, Uniformed Services University, Bethesda, Maryland
  • ,
  • Jennifer C Cullen, Department of Family Medicine, Uniformed Services of Health Sciences, Uniformed Services University, Bethesda, Maryland
  • ,
  • Gyorgy Petrovics, Department of Family Medicine, Uniformed Services of Health Sciences, Uniformed Services University, Bethesda, Maryland
  • ,
  • Graham Casey, Virginia Commonwealth University, Virginia
  • ,
  • Monique J Roobol, Erasmus University Medical Center Cancer Institute, Department of Obstetrics and Gynaecology, Erasmus University Medical Center.
  • ,
  • Guido Jenster, Erasmus University Medical Center Cancer Institute, Department of Obstetrics and Gynaecology, Erasmus University Medical Center.
  • ,
  • Ron H N van Schaik, Erasmus University Medical Center Cancer Institute, Department of Obstetrics and Gynaecology, Erasmus University Medical Center.
  • ,
  • Jennifer J Hu, The Miami Project to Cure Paralysis, University of Miami, Miller School of Medicine, FL
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  • Maureen Sanderson, Meharry Medical College
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  • Rohit Varma, Southern California Eye Institute
  • ,
  • Roberta McKean-Cowdin, University of Southern California/Norris Comprehensive Cancer Center
  • ,
  • Mina Torres, Southern California Eye Institute
  • ,
  • Nicholas Mancuso, University of Southern California/Norris Comprehensive Cancer Center
  • ,
  • Sonja I Berndt, National Institute of Health's National Cancer Institute: Quantitative Imaging Network
  • ,
  • Stephen K Van Den Eeden, Research Division
  • ,
  • Douglas F Easton, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom;
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  • Stephen J Chanock, National Institute of Health's National Cancer Institute: Quantitative Imaging Network
  • ,
  • Michael B Cook, National Institute of Health's National Cancer Institute: Quantitative Imaging Network
  • ,
  • Fredrik Wiklund, Karolinska University Hospital og Karolinska Institute
  • ,
  • Hidewaki Nakagawa, Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
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  • John S Witte, Department of Dermatology, University of California, San Diego, California; Department of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego, California.
  • ,
  • Rosalind A Eeles, The Royal Marsden / The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre, London, UK.
  • ,
  • Zsofia Kote-Jarai, The Royal Marsden / The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre, London, UK.
  • ,
  • Christopher A Haiman, University of Southern California/Norris Comprehensive Cancer Center

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.

OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind53
Nummer1
Sider (fra-til)65-75
Antal sider11
ISSN1061-4036
DOI
StatusUdgivet - jan. 2021

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