Trafficking of B cell antigen in lymph nodes

Santiago F. Gonzalez; Søren Egedal Degn; Lisa A. Pitcher; Matthew Woodruff; Balthasar A. Heesters; Michael C. Carroll

Trafficking of B cell antigen in lymph nodes

Bidragets oversatte titel: Transport af B celle antigen i lymfeknuder

Santiago F. Gonzalez, Søren Egedal Degn, Lisa A. Pitcher, Matthew Woodruff, Balthasar A. Heesters, Michael C. Carroll

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

122 Citationer (Scopus)

Abstract

The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4, 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.

Bidragets oversatte titel	Transport af B celle antigen i lymfeknuder
Originalsprog	Engelsk
Tidsskrift	Annual Review of Immunology
Vol/bind	29
Sider (fra-til)	215-233
Antal sider	19
ISSN	0732-0582
Status	Udgivet - 2011

Citationsformater

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abstract = "The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4, 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.",

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T1 - Trafficking of B cell antigen in lymph nodes

AU - Gonzalez, Santiago F.

AU - Degn, Søren Egedal

AU - Pitcher, Lisa A.

AU - Woodruff, Matthew

AU - Heesters, Balthasar A.

AU - Carroll, Michael C.

PY - 2011

Y1 - 2011

N2 - The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4, 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.

AB - The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4, 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.

M3 - Journal article

SN - 0732-0582

VL - 29

SP - 215

EP - 233

JO - Annual Review of Immunology

JF - Annual Review of Immunology

ER -