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Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology

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Toxins, Targets, and Triggers : An Overview of Toxin-Antitoxin Biology. / Harms, Alexander; Brodersen, Ditlev Egeskov; Mitarai, Namiko; Gerdes, Kenn.

I: Molecular Cell, Bind 70, Nr. 5, 07.06.2018, s. 768-784.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

Harvard

Harms, A, Brodersen, DE, Mitarai, N & Gerdes, K 2018, 'Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology', Molecular Cell, bind 70, nr. 5, s. 768-784. https://doi.org/10.1016/j.molcel.2018.01.003

APA

Harms, A., Brodersen, D. E., Mitarai, N., & Gerdes, K. (2018). Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology. Molecular Cell, 70(5), 768-784. https://doi.org/10.1016/j.molcel.2018.01.003

CBE

Harms A, Brodersen DE, Mitarai N, Gerdes K. 2018. Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology. Molecular Cell. 70(5):768-784. https://doi.org/10.1016/j.molcel.2018.01.003

MLA

Harms, Alexander o.a.. "Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology". Molecular Cell. 2018, 70(5). 768-784. https://doi.org/10.1016/j.molcel.2018.01.003

Vancouver

Harms A, Brodersen DE, Mitarai N, Gerdes K. Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology. Molecular Cell. 2018 jun 7;70(5):768-784. https://doi.org/10.1016/j.molcel.2018.01.003

Author

Harms, Alexander ; Brodersen, Ditlev Egeskov ; Mitarai, Namiko ; Gerdes, Kenn. / Toxins, Targets, and Triggers : An Overview of Toxin-Antitoxin Biology. I: Molecular Cell. 2018 ; Bind 70, Nr. 5. s. 768-784.

Bibtex

@article{484c7f09e9e043dfabb3043c4e5bd8a8,
title = "Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology",
abstract = "Bacterial toxin-antitoxin (TA) modules are abundant genetic elements that encode a toxin protein capable of inhibiting cell growth and an antitoxin that counteracts the toxin. The majority of toxins are enzymes that interfere with translation or DNA replication, but a wide variety of molecular activities and cellular targets have been described. Antitoxins are proteins or RNAs that often control their cognate toxins through direct interactions and, in conjunction with other signaling elements, through transcriptional and translational regulation of TA module expression. Three major biological functions of TA modules have been discovered, post-segregational killing (“plasmid addiction”), abortive infection (bacteriophage immunity through altruistic suicide), and persister formation (antibiotic tolerance through dormancy). In this review, we summarize the current state of the field and highlight how multiple levels of regulation shape the conditions of toxin activation to achieve the different biological functions of TA modules. Bacterial toxin-antitoxin (TA) modules are abundant genetic elements encoding a toxin that inhibits cell growth and an antitoxin that counteracts the toxin. Harms et al. review recent developments in the field and highlight how multiple levels of regulation control toxin activation to accomplish the diverse biological functions of TA modules.",
keywords = "RNA biology, abortive infection, antibiotic tolerance, bacterial persistence, conditional cooperativity, plasmid addiction, post-segregational killing, toxin-antitoxin modules",
author = "Alexander Harms and Brodersen, {Ditlev Egeskov} and Namiko Mitarai and Kenn Gerdes",
note = "Copyright {\textcopyright} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
month = jun,
day = "7",
doi = "10.1016/j.molcel.2018.01.003",
language = "English",
volume = "70",
pages = "768--784",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Toxins, Targets, and Triggers

T2 - An Overview of Toxin-Antitoxin Biology

AU - Harms, Alexander

AU - Brodersen, Ditlev Egeskov

AU - Mitarai, Namiko

AU - Gerdes, Kenn

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/6/7

Y1 - 2018/6/7

N2 - Bacterial toxin-antitoxin (TA) modules are abundant genetic elements that encode a toxin protein capable of inhibiting cell growth and an antitoxin that counteracts the toxin. The majority of toxins are enzymes that interfere with translation or DNA replication, but a wide variety of molecular activities and cellular targets have been described. Antitoxins are proteins or RNAs that often control their cognate toxins through direct interactions and, in conjunction with other signaling elements, through transcriptional and translational regulation of TA module expression. Three major biological functions of TA modules have been discovered, post-segregational killing (“plasmid addiction”), abortive infection (bacteriophage immunity through altruistic suicide), and persister formation (antibiotic tolerance through dormancy). In this review, we summarize the current state of the field and highlight how multiple levels of regulation shape the conditions of toxin activation to achieve the different biological functions of TA modules. Bacterial toxin-antitoxin (TA) modules are abundant genetic elements encoding a toxin that inhibits cell growth and an antitoxin that counteracts the toxin. Harms et al. review recent developments in the field and highlight how multiple levels of regulation control toxin activation to accomplish the diverse biological functions of TA modules.

AB - Bacterial toxin-antitoxin (TA) modules are abundant genetic elements that encode a toxin protein capable of inhibiting cell growth and an antitoxin that counteracts the toxin. The majority of toxins are enzymes that interfere with translation or DNA replication, but a wide variety of molecular activities and cellular targets have been described. Antitoxins are proteins or RNAs that often control their cognate toxins through direct interactions and, in conjunction with other signaling elements, through transcriptional and translational regulation of TA module expression. Three major biological functions of TA modules have been discovered, post-segregational killing (“plasmid addiction”), abortive infection (bacteriophage immunity through altruistic suicide), and persister formation (antibiotic tolerance through dormancy). In this review, we summarize the current state of the field and highlight how multiple levels of regulation shape the conditions of toxin activation to achieve the different biological functions of TA modules. Bacterial toxin-antitoxin (TA) modules are abundant genetic elements encoding a toxin that inhibits cell growth and an antitoxin that counteracts the toxin. Harms et al. review recent developments in the field and highlight how multiple levels of regulation control toxin activation to accomplish the diverse biological functions of TA modules.

KW - RNA biology

KW - abortive infection

KW - antibiotic tolerance

KW - bacterial persistence

KW - conditional cooperativity

KW - plasmid addiction

KW - post-segregational killing

KW - toxin-antitoxin modules

U2 - 10.1016/j.molcel.2018.01.003

DO - 10.1016/j.molcel.2018.01.003

M3 - Review

C2 - 29398446

VL - 70

SP - 768

EP - 784

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 5

ER -