Toenail selenium, plasma selenoprotein P and risk of advanced prostate cancer: a nested case-control study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Malene Outzen, Danish Cancer Society Research Center, The Danish Cancer Society, Copenhagen, Division for Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Søborg, Denmark., Danmark
  • Anne Tjønneland, Danish Cancer Society Research Center, The Danish Cancer Society, Copenhagen, Danmark
  • David J Hughes, University College Dublin, Dublin, Irland
  • Mazda Jenab, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France., Frankrig
  • Kirsten Frederiksen, Danish Cancer Society Research Center, The Danish Cancer Society, Copenhagen, Danmark
  • Lutz Schomburg, Charité-Universitätsmedizin Berlin, Tyskland
  • Steve Morris, University of Missouri Research Reactor Center, USA
  • Kim Overvad
  • Anja Olsen

Low selenium status may be associated with increased risk of prostate cancer (PC), particularly aggressive PC, and variation in selenoprotein genes may constitute an important modifying factor. We aimed to investigate the association between two selenium status biomarkers [toenail selenium, plasma selenoprotein P (SELENOP)] and risk of advanced, high-grade, and advanced-stage PC. We further studied whether variations in selenoprotein genes were associated with PC risk and selenium biomarker concentrations. In the "Diet, Cancer and Health" cohort, 27 178 men aged 50-65 years were enrolled during 1993-1997. Between baseline and 2012, 1160 cohort participants were diagnosed with advanced PC; among these 462 had high-grade and 281 had advanced-stage disease at diagnosis. Each case was risk set-matched to one control. Toenail selenium and plasma SELENOP concentrations were measured by neutron activation analysis and a SELENOP-ELISA, respectively, and genotyping was performed for 27 selected single nucleotide polymorphisms (SNPs) in 12 selenium pathway genes (including 7 selenoproteins) by allele-specific PCR. Toenail selenium and circulating SELENOP concentrations were not associated with advanced, high-grade or advanced-stage PC. After adjustment for multiple testing, none of the genes were associated with PC risk. Neither toenail selenium nor plasma SELENOP were associated with advanced, high-grade or advanced-stage PC.

OriginalsprogEngelsk
Artikelnummer33267
TidsskriftInternational Journal of Cancer
Vol/bind148
Nummer4
Sider (fra-til)876-883
Antal sider8
ISSN0020-7136
DOI
StatusUdgivet - feb. 2021

Bibliografisk note

This article is protected by copyright. All rights reserved.

Se relationer på Aarhus Universitet Citationsformater

ID: 195342829