Tobacco smoking and alcohol consumption as risk factors for thymoma: A European case-control study

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DOI

  • Mikael Eriksson, Lunds Universitet
  • ,
  • Linda Kaerlev, Research Unit of Clinical Epidemiology, Syddansk Universitet, Centre for Clinical Epidemiology, Odense Universitetshospital
  • ,
  • Preben Johansen, Institute of Pathology
  • ,
  • Noemia Afonso, Portuguese Oncology Institute of Porto
  • ,
  • Wolfgang Ahrens, Leibniz Institute for Prevention Research and Epidemiology
  • ,
  • Altamiro Costa-Pereira, Universidade do Porto
  • ,
  • Pascal Guénel, University Paris-South, Université Paris-Sud 11
  • ,
  • Karl Heinz Jöckel, University Clinics Essen
  • ,
  • Agustin Llopis Gonzalez, Universitat Politècnica de València, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)
  • ,
  • Franco Merletti, Università degli Studi di Torino
  • ,
  • Maria Morales Suárez-Varela, Universitat Politècnica de València, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)
  • ,
  • Brigitte Trétarre, Registre des Tumeurs de l´Hérault
  • ,
  • Gun Wingren, Linköping University
  • ,
  • Lorenzo Richiardi, Università degli Studi di Padova
  • ,
  • Svend Sabroe

Purpose: Hardly anything is known about the aetiology of thymoma. This paper presents data regarding tobacco smoking and alcohol consumption in relation to thymoma from the first case-control study performed on this rare tumour. Methods: A European multi-centre case-control study including incident cases aged 35–69 years with thymoma between 1995 and 1997, was conducted in seven countries. A set of controls, used in seven parallel case-control studies by the same research group was used, including population-based controls from five countries and hospital controls with colon cancer from two countries. Altogether 103 cases, accepted by a reference pathologist, 712 colon cancer controls, and 2071 population controls were interviewed. Results: Tobacco smoking was moderately related with thymoma (OR 1.4, 95% CI 0.9–2.2), and a tendency to dose-response was shown (p = 0.04), with an increased risk for heavy smokers defined as ≥41 pack-years (OR 2.1, 95% CI 1.1–3.9). A high consumption of spirits defined as ≥25 g of alcohol per day was associated with an increased risk of thymoma (OR 2.4, 95% CI 1.1–5.4), whereas no association was found with beer or wine. Conclusions: Tobacco smoking and a high intake of spirits were indicated as risk factors for thymoma.

OriginalsprogEngelsk
TidsskriftCancer epidemiology
Vol/bind61
Sider (fra-til)133-138
Antal sider6
ISSN1877-7821
DOI
StatusUdgivet - 2019

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