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TMAO (trimethylamine oxide)-independence of oxygen affinity and its urea and ATP sensitivities in an elasmobranch hemoglobin

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TMAO (trimethylamine oxide)-independence of oxygen affinity and its urea and ATP sensitivities in an elasmobranch hemoglobin. / Weber, Roy E.

I: The Journal of experimental zoology, Bind 228, Nr. 3, 1983, s. 551-4.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{368e7c20001945cc829797886c9ff040,
title = "TMAO (trimethylamine oxide)-independence of oxygen affinity and its urea and ATP sensitivities in an elasmobranch hemoglobin",
abstract = "Urea and trimethylamine oxide (TMAO), the major osmolytes in the body fluids of marine elasmobranch fishes, are known to exert counteracting effects on the functions of a variety of enzymes and other proteins of vertebrates (cf. Yancey et al., '82). Although urea raises the O2 affinity of the hemoglobin (Hb) of Squalus acanthias and reduces its sensitivity to the major allosteric cofactor, ATP, the oxygenation reactions of the Hb are insensitive to TMAO, reflecting the absence of urea-TMAO counteraction in the absence or in the presence of the phosphate.",
keywords = "Adenosine Triphosphate, Animals, Dogfish, Hemoglobins, Methylamines, Oxygen, Oxyhemoglobins, Sharks, Urea",
author = "Weber, {Roy E.}",
year = "1983",
doi = "10.1002/jez.1402280315",
language = "English",
volume = "228",
pages = "551--4",
journal = "Journal of Experimental Zoology. Part A: Ecological Genetics and Physiology (Print Edition)",
issn = "1932-5223",
publisher = "JohnWiley & Sons, Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - TMAO (trimethylamine oxide)-independence of oxygen affinity and its urea and ATP sensitivities in an elasmobranch hemoglobin

AU - Weber, Roy E.

PY - 1983

Y1 - 1983

N2 - Urea and trimethylamine oxide (TMAO), the major osmolytes in the body fluids of marine elasmobranch fishes, are known to exert counteracting effects on the functions of a variety of enzymes and other proteins of vertebrates (cf. Yancey et al., '82). Although urea raises the O2 affinity of the hemoglobin (Hb) of Squalus acanthias and reduces its sensitivity to the major allosteric cofactor, ATP, the oxygenation reactions of the Hb are insensitive to TMAO, reflecting the absence of urea-TMAO counteraction in the absence or in the presence of the phosphate.

AB - Urea and trimethylamine oxide (TMAO), the major osmolytes in the body fluids of marine elasmobranch fishes, are known to exert counteracting effects on the functions of a variety of enzymes and other proteins of vertebrates (cf. Yancey et al., '82). Although urea raises the O2 affinity of the hemoglobin (Hb) of Squalus acanthias and reduces its sensitivity to the major allosteric cofactor, ATP, the oxygenation reactions of the Hb are insensitive to TMAO, reflecting the absence of urea-TMAO counteraction in the absence or in the presence of the phosphate.

KW - Adenosine Triphosphate

KW - Animals

KW - Dogfish

KW - Hemoglobins

KW - Methylamines

KW - Oxygen

KW - Oxyhemoglobins

KW - Sharks

KW - Urea

U2 - 10.1002/jez.1402280315

DO - 10.1002/jez.1402280315

M3 - Journal article

C2 - 6663264

VL - 228

SP - 551

EP - 554

JO - Journal of Experimental Zoology. Part A: Ecological Genetics and Physiology (Print Edition)

JF - Journal of Experimental Zoology. Part A: Ecological Genetics and Physiology (Print Edition)

SN - 1932-5223

IS - 3

ER -