Thromboembolic and bleeding risk in atrial fibrillation patients undergoing percutaneous coronary intervention, during a 15-year period in Western Denmark

Publikation: KonferencebidragKonferenceabstrakt til konferenceForskning

Atrial fibrillation (AF) patients require oral anticoagulants (OAC) to decrease risk of thromboembolism. In 2012, European guidelines changed their recommendation to dual antiplatelet therapy (DAPT) in addition to OAC (triple therapy) in AF patients who undergo percutaneous coronary intervention (PCI). However, triple therapy doubles risk of bleeding. This study will evaluate changes in thromboembolic events and bleeding in AF patients that underwent PCI from 2003 to 2017.

Materials and methods
All patients with atrial fibrillation, who underwent PCI between 2003--2017, will be included 14 days after their first PCI and will be followed for 1 year. Patients will be divided into 3 groups based on treatment year (2003--2007, 2008--2012 and 2013--2017). The main endpoints are major adverse cardiac events and bleeding. Risks will be compared using poisson regression. Patient data will be obtained using the Western Denmark Heart registry and Danish national health registries.

Preliminary results show inclusion of 6 599 patients. Of these, 1 932 treated between 2003--2007, 2 083 in 2008--2012 and 2 584 in 2013--2017. Analyses are yet incomplete, and final results will be presented at KMS 2021.

The study will evaluate changes in thromboembolic and bleeding risk in AF patients undergoing PCI from 2003 to 2017.

KKWO has received speaking fee from Bayer.
SDK has received speakers fee from Aspen and AstraZeneca.
MM has received advisory board fees from Boehringer-Ingelheim, AstraZeneca, Novo Nordisk, BMS, Boston Scientific, and Bayer.
We would like to thank the department of Cardiology, Aarhus University hospital.

Follow-up study
Atrial fibrillation
Percutaneous coronary intervention
StatusUdgivet - 2021
BegivenhedKongress for Medicinsk Studenterforskning -
Varighed: 11 mar. 202114 mar. 2021


KonferenceKongress for Medicinsk Studenterforskning

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