Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial

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Thiamine as an adjunctive therapy in cardiac surgery : a randomized, double-blind, placebo-controlled, phase II trial. / Wiuff Andersen, Lars; Holmberg, Mathias J; Berg, KM; Chase, M; Cocchi, MN; Sulmonte, C; Balkema, J; MacDonald, M; Montissol, S; Senthilnathan, V; Liu, D; Khabbaz, K; Lerner, A; Novack, V; Liu, X; Donnino, MW.

I: Critical Care, Bind 20, 92, 2016.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Wiuff Andersen, L, Holmberg, MJ, Berg, KM, Chase, M, Cocchi, MN, Sulmonte, C, Balkema, J, MacDonald, M, Montissol, S, Senthilnathan, V, Liu, D, Khabbaz, K, Lerner, A, Novack, V, Liu, X & Donnino, MW 2016, 'Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial', Critical Care, bind 20, 92. https://doi.org/10.1186/s13054-016-1245-1

APA

CBE

Wiuff Andersen L, Holmberg MJ, Berg KM, Chase M, Cocchi MN, Sulmonte C, Balkema J, MacDonald M, Montissol S, Senthilnathan V, Liu D, Khabbaz K, Lerner A, Novack V, Liu X, Donnino MW. 2016. Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial. Critical Care. 20. https://doi.org/10.1186/s13054-016-1245-1

MLA

Vancouver

Author

Wiuff Andersen, Lars ; Holmberg, Mathias J ; Berg, KM ; Chase, M ; Cocchi, MN ; Sulmonte, C ; Balkema, J ; MacDonald, M ; Montissol, S ; Senthilnathan, V ; Liu, D ; Khabbaz, K ; Lerner, A ; Novack, V ; Liu, X ; Donnino, MW. / Thiamine as an adjunctive therapy in cardiac surgery : a randomized, double-blind, placebo-controlled, phase II trial. I: Critical Care. 2016 ; Bind 20.

Bibtex

@article{a03d9ed76460470bba51f4971804f45e,
title = "Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial",
abstract = "BACKGROUND: Thiamine is a vitamin that is essential for adequate aerobic metabolism. The objective of this study was to determine if thiamine administration prior to coronary artery bypass grafting would decrease post-operative lactate levels as a measure of increased aerobic metabolism.METHODS: We performed a randomized, double-blind, placebo-controlled trial of patients undergoing coronary artery bypass grafting. Patients were randomized to receive either intravenous thiamine (200 mg) or placebo both immediately before and again after the surgery. Our primary endpoint was post-operative lactate levels. Additional endpoints included pyruvate dehydrogenase activity, global and cellular oxygen consumption, post-operative complications, and hospital and intensive care unit length of stay.RESULTS: Sixty-four patients were included. Thiamine levels were significantly higher in the thiamine group as compared to the placebo group immediately after surgery (1200 [683, 1200] nmol/L vs. 9 [8, 13] nmol/L, p < 0.001). There was no difference between the groups in the primary endpoint of lactate levels immediately after the surgery (2.0 [1.5, 2.6] mmol/L vs. 2.0 [1.7, 2.4], p = 0.75). Relative pyruvate dehydrogenase activity was lower immediately after the surgery in the thiamine group as compared to the placebo group (15{\%} [11, 37] vs. 28{\%} [15, 84], p = 0.02). Patients receiving thiamine had higher post-operative global oxygen consumption 1 hour after the surgery (difference: 0.37 mL/min/kg [95{\%} CI: 0.03, 0.71], p = 0.03) as well as cellular oxygen consumption. We found no differences in clinical outcomes.CONCLUSIONS: There were no differences in post-operative lactate levels or clinical outcomes between patients receiving thiamine or placebo. Post-operative oxygen consumption was significantly increased among patients receiving thiamine.TRIAL REGISTRATION: clinicaltrials.gov NCT02322892, December 14, 2014.",
author = "{Wiuff Andersen}, Lars and Holmberg, {Mathias J} and KM Berg and M Chase and MN Cocchi and C Sulmonte and J Balkema and M MacDonald and S Montissol and V Senthilnathan and D Liu and K Khabbaz and A Lerner and V Novack and X Liu and MW Donnino",
year = "2016",
doi = "10.1186/s13054-016-1245-1",
language = "English",
volume = "20",
journal = "Critical Care (Online Edition)",
issn = "1466-609X",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Thiamine as an adjunctive therapy in cardiac surgery

T2 - a randomized, double-blind, placebo-controlled, phase II trial

AU - Wiuff Andersen, Lars

AU - Holmberg, Mathias J

AU - Berg, KM

AU - Chase, M

AU - Cocchi, MN

AU - Sulmonte, C

AU - Balkema, J

AU - MacDonald, M

AU - Montissol, S

AU - Senthilnathan, V

AU - Liu, D

AU - Khabbaz, K

AU - Lerner, A

AU - Novack, V

AU - Liu, X

AU - Donnino, MW

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Thiamine is a vitamin that is essential for adequate aerobic metabolism. The objective of this study was to determine if thiamine administration prior to coronary artery bypass grafting would decrease post-operative lactate levels as a measure of increased aerobic metabolism.METHODS: We performed a randomized, double-blind, placebo-controlled trial of patients undergoing coronary artery bypass grafting. Patients were randomized to receive either intravenous thiamine (200 mg) or placebo both immediately before and again after the surgery. Our primary endpoint was post-operative lactate levels. Additional endpoints included pyruvate dehydrogenase activity, global and cellular oxygen consumption, post-operative complications, and hospital and intensive care unit length of stay.RESULTS: Sixty-four patients were included. Thiamine levels were significantly higher in the thiamine group as compared to the placebo group immediately after surgery (1200 [683, 1200] nmol/L vs. 9 [8, 13] nmol/L, p < 0.001). There was no difference between the groups in the primary endpoint of lactate levels immediately after the surgery (2.0 [1.5, 2.6] mmol/L vs. 2.0 [1.7, 2.4], p = 0.75). Relative pyruvate dehydrogenase activity was lower immediately after the surgery in the thiamine group as compared to the placebo group (15% [11, 37] vs. 28% [15, 84], p = 0.02). Patients receiving thiamine had higher post-operative global oxygen consumption 1 hour after the surgery (difference: 0.37 mL/min/kg [95% CI: 0.03, 0.71], p = 0.03) as well as cellular oxygen consumption. We found no differences in clinical outcomes.CONCLUSIONS: There were no differences in post-operative lactate levels or clinical outcomes between patients receiving thiamine or placebo. Post-operative oxygen consumption was significantly increased among patients receiving thiamine.TRIAL REGISTRATION: clinicaltrials.gov NCT02322892, December 14, 2014.

AB - BACKGROUND: Thiamine is a vitamin that is essential for adequate aerobic metabolism. The objective of this study was to determine if thiamine administration prior to coronary artery bypass grafting would decrease post-operative lactate levels as a measure of increased aerobic metabolism.METHODS: We performed a randomized, double-blind, placebo-controlled trial of patients undergoing coronary artery bypass grafting. Patients were randomized to receive either intravenous thiamine (200 mg) or placebo both immediately before and again after the surgery. Our primary endpoint was post-operative lactate levels. Additional endpoints included pyruvate dehydrogenase activity, global and cellular oxygen consumption, post-operative complications, and hospital and intensive care unit length of stay.RESULTS: Sixty-four patients were included. Thiamine levels were significantly higher in the thiamine group as compared to the placebo group immediately after surgery (1200 [683, 1200] nmol/L vs. 9 [8, 13] nmol/L, p < 0.001). There was no difference between the groups in the primary endpoint of lactate levels immediately after the surgery (2.0 [1.5, 2.6] mmol/L vs. 2.0 [1.7, 2.4], p = 0.75). Relative pyruvate dehydrogenase activity was lower immediately after the surgery in the thiamine group as compared to the placebo group (15% [11, 37] vs. 28% [15, 84], p = 0.02). Patients receiving thiamine had higher post-operative global oxygen consumption 1 hour after the surgery (difference: 0.37 mL/min/kg [95% CI: 0.03, 0.71], p = 0.03) as well as cellular oxygen consumption. We found no differences in clinical outcomes.CONCLUSIONS: There were no differences in post-operative lactate levels or clinical outcomes between patients receiving thiamine or placebo. Post-operative oxygen consumption was significantly increased among patients receiving thiamine.TRIAL REGISTRATION: clinicaltrials.gov NCT02322892, December 14, 2014.

U2 - 10.1186/s13054-016-1245-1

DO - 10.1186/s13054-016-1245-1

M3 - Journal article

C2 - 27044557

VL - 20

JO - Critical Care (Online Edition)

JF - Critical Care (Online Edition)

SN - 1466-609X

M1 - 92

ER -