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Thermoregulation in Post-cardiac Arrest Patients Treated with Targeted Temperature Management

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Anne Kirstine Hoeyer-Nielsen, Beth Israel Deaconess Medical Center, Aalborg Universitet
  • ,
  • Mathias J Holmberg
  • Erika F Christensen
  • Michael N Cocchi, Beth Israel Deaconess Medical Center
  • ,
  • Michael W Donnino, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • ,
  • Anne V Grossestreuer, Beth Israel Deaconess Medical Center

OBJECTIVE: Evaluate the relationship between heat generation during rewarming in post-cardiac arrest patients receiving targeted temperature management (TTM) as a surrogate of thermoregulatory ability and clinical outcomes.

METHODS: This is a prospective observational single-center study conducted at an urban tertiary-care hospital. We included post-cardiac arrest adults who received TTM via surface cooling device between April 2018 and June 2019.

RESULTS: Patient heat generation was calculated by multiplying the inverse of the average machine water temperature with time to rewarm to 37°C and standardized in two ways to account for target temperature variation: (1) divided by number of degrees between target temperature and 37°C, and (2) limited to when patient was rewarmed from 36°C to 37°C. The primary outcome was poor neurologic status, defined as Cerebral Performance Category (CPC) score 3-5, and the secondary outcome was 30-day survival. Sixty-six patients were included: 45 (68%) had a CPC-score of 3-5 and 23 (35%) were alive at 30 days. Besides initial rhythm and arrest downtime, baseline characteristics were similar between outcomes. Heat generation was not associated with poor neurological outcome (CPC 3-5: 6.6 [IQR: 6.1, 7.4] versus CPC 1-2: 6.6 [IQR: 5.7, 7.6], p=0.89) or survival at 30 days (non-survivors: 6.6 [IQR: 6.6, 7.4] vs. survivors: 6.6 [IQR: 5.7, 8.0, p=0.78]).

CONCLUSION: Heat generation during rewarming was not associated with neurologic outcomes. However, there was a relationship between poor neurological outcome and higher median water temperatures. Time to rewarm was prolonged in patients with poor neurological outcome.

OriginalsprogEngelsk
TidsskriftResuscitation
Vol/bind162
Sider (fra-til)63-69
Antal sider7
ISSN0300-9572
DOI
StatusUdgivet - maj 2021

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