The utility of a point-of-care sural nerve conduction device for detection of diabetic polyneuropathy: A cross-sectional study

TY - JOUR

T1 - The utility of a point-of-care sural nerve conduction device for detection of diabetic polyneuropathy

T2 - A cross-sectional study

AU - Kural, Mustafa A

AU - Andersen, Signe T

AU - Andersen, Niels T

AU - Andersen, Henning

AU - Charles, Morten

AU - Finnerup, Nanna B

AU - Jensen, Troels S

AU - Tankisi, Hatice

N1 - © 2018 Wiley Periodicals, Inc.

PY - 2019/2

Y1 - 2019/2

N2 - Introduction: Rapid and accessible methods for diagnosing diabetic polyneuropathy (DPN) have been developed, but not validated, in large cohorts of people with diabetes. Methods: The performance of a point-of-care device (POCD) was studied in 168 patients with type 2 diabetes, estimating the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) compared with conventional sural nerve conduction studies (NCS). Results: A POCD amplitude limit of 6 µV increased the sensitivity (96%) and NPV (98%), but decreased the specificity (71%) and PPV (54%) compared with the 4-µV limit, which had values of 78%, 92%, 89%, and 71%, respectively. POCD on both legs showed better performance than on 1 leg. POCD amplitudes and conduction velocities correlated significantly with conventional sural NCS, but POCD values were underestimated compared with NCS. Discussion: The POCD may be used as a suitable screening tool for detection of DPN. Patients with abnormal and borderline results should undergo conventional NCS. Muscle Nerve 59:187–193, 2019.

AB - Introduction: Rapid and accessible methods for diagnosing diabetic polyneuropathy (DPN) have been developed, but not validated, in large cohorts of people with diabetes. Methods: The performance of a point-of-care device (POCD) was studied in 168 patients with type 2 diabetes, estimating the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) compared with conventional sural nerve conduction studies (NCS). Results: A POCD amplitude limit of 6 µV increased the sensitivity (96%) and NPV (98%), but decreased the specificity (71%) and PPV (54%) compared with the 4-µV limit, which had values of 78%, 92%, 89%, and 71%, respectively. POCD on both legs showed better performance than on 1 leg. POCD amplitudes and conduction velocities correlated significantly with conventional sural NCS, but POCD values were underestimated compared with NCS. Discussion: The POCD may be used as a suitable screening tool for detection of DPN. Patients with abnormal and borderline results should undergo conventional NCS. Muscle Nerve 59:187–193, 2019.

KW - POCD

KW - diabetic polyneuropathy

KW - nerve conduction study

KW - point-of-care nerve conduction device

KW - sural nerve

KW - TRIAL

KW - TESTS

KW - MULTIFACTORIAL THERAPY

KW - PEOPLE

KW - OUTCOMES

U2 - 10.1002/mus.26361

DO - 10.1002/mus.26361

M3 - Journal article

C2 - 30582180

SN - 0148-639X

VL - 59

SP - 187

EP - 193

JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 2

ER -