The role of O-GlcNAcylation in development

Ignacy Czajewski; Daan M F van Aalten

doi:10.1242/dev.201370

The role of O-GlcNAcylation in development

Ignacy Czajewski
, Daan M F van Aalten^*

^*Corresponding author af dette arbejde

Institut for Molekylærbiologi og Genetik - Cellulær sundhed, intervention og ernæring

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

14 Citationer (Scopus)

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Abstract

O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.

Originalsprog	Engelsk
Artikelnummer	dev201370
Tidsskrift	Development
Vol/bind	150
Nummer	6
ISSN	0950-1991
DOI	https://doi.org/10.1242/dev.201370
Status	Udgivet - mar. 2023

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10.1242/dev.201370Licens: CC BY

dev201370Forlagets udgivne version, 597 KBLicens: CC BY

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The role of O-GlcNAcylation in development

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