The role of IFN in the development of NAFLD and NASH

Michelle Møhlenberg; Ewa Terczynska-Dyla; Karen Louise Thomsen; Jacob George; Mohammed Eslam; Henning Grønbæk; Rune Hartmann

doi:10.1016/j.cyto.2018.08.013

The role of IFN in the development of NAFLD and NASH

Michelle Møhlenberg, Ewa Terczynska-Dyla, Karen Louise Thomsen, Jacob George, Mohammed Eslam, Henning Grønbæk, Rune Hartmann^*

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin - Lever-, Mave- og Tarmsygdomme

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

Non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) are major health challenges due to a significant increase in their incidence and prevalence. While NAFLD is largely benign, the chronic liver inflammation in NASH patients may cause progression to liver cirrhosis and hepatocellular carcinoma. There is an urgent need for a better understanding of the factors, which drive the progression from NAFLD to NASH and how to use this information both to improve diagnostic and to develop new treatment strategies. Increasing evidence points to interferons (IFNs) as key players in NAFLD and particular in the progression to NASH. IFNs crucial role in disease development is supported by both genetic evidence and animal studies. In this review, we describe the involvement of both type I and type III IFNs in the development and progression of NAFLD and NASH.

Originalsprog	Engelsk
Artikelnummer	154519
Tidsskrift	Cytokine
Vol/bind	124
Antal sider	6
ISSN	1043-4666
DOI	https://doi.org/10.1016/j.cyto.2018.08.013
Status	Udgivet - 2019

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title = "The role of IFN in the development of NAFLD and NASH",

abstract = "Non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) are major health challenges due to a significant increase in their incidence and prevalence. While NAFLD is largely benign, the chronic liver inflammation in NASH patients may cause progression to liver cirrhosis and hepatocellular carcinoma. There is an urgent need for a better understanding of the factors, which drive the progression from NAFLD to NASH and how to use this information both to improve diagnostic and to develop new treatment strategies. Increasing evidence points to interferons (IFNs) as key players in NAFLD and particular in the progression to NASH. IFNs crucial role in disease development is supported by both genetic evidence and animal studies. In this review, we describe the involvement of both type I and type III IFNs in the development and progression of NAFLD and NASH.",

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author = "Michelle M{\o}hlenberg and Ewa Terczynska-Dyla and Thomsen, {Karen Louise} and Jacob George and Mohammed Eslam and Henning Gr{\o}nb{\ae}k and Rune Hartmann",

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language = "English",

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T1 - The role of IFN in the development of NAFLD and NASH

AU - Møhlenberg, Michelle

AU - Terczynska-Dyla, Ewa

AU - Thomsen, Karen Louise

AU - George, Jacob

AU - Eslam, Mohammed

AU - Grønbæk, Henning

AU - Hartmann, Rune

PY - 2019

Y1 - 2019

N2 - Non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) are major health challenges due to a significant increase in their incidence and prevalence. While NAFLD is largely benign, the chronic liver inflammation in NASH patients may cause progression to liver cirrhosis and hepatocellular carcinoma. There is an urgent need for a better understanding of the factors, which drive the progression from NAFLD to NASH and how to use this information both to improve diagnostic and to develop new treatment strategies. Increasing evidence points to interferons (IFNs) as key players in NAFLD and particular in the progression to NASH. IFNs crucial role in disease development is supported by both genetic evidence and animal studies. In this review, we describe the involvement of both type I and type III IFNs in the development and progression of NAFLD and NASH.

AB - Non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) are major health challenges due to a significant increase in their incidence and prevalence. While NAFLD is largely benign, the chronic liver inflammation in NASH patients may cause progression to liver cirrhosis and hepatocellular carcinoma. There is an urgent need for a better understanding of the factors, which drive the progression from NAFLD to NASH and how to use this information both to improve diagnostic and to develop new treatment strategies. Increasing evidence points to interferons (IFNs) as key players in NAFLD and particular in the progression to NASH. IFNs crucial role in disease development is supported by both genetic evidence and animal studies. In this review, we describe the involvement of both type I and type III IFNs in the development and progression of NAFLD and NASH.

KW - Animal models

KW - Humans and human genetics

KW - Interferons (IFN) type I IFN and type III IFN

KW - Non-alcoholic fatty liver disease (NAFLD)

KW - Non-alcoholic steatohepatitis (NASH)

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DO - 10.1016/j.cyto.2018.08.013

M3 - Journal article

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AN - SCOPUS:85051740828

SN - 1043-4666

VL - 124

JO - Cytokine

JF - Cytokine

M1 - 154519

ER -

The role of IFN in the development of NAFLD and NASH

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