Aarhus University Seal / Aarhus Universitets segl

The role of H1 antihistamines in contralateral breast cancer: a Danish nationwide cohort study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Annet Bens, Kræftens Bekæmpelse
  • ,
  • Christian Dehlendorff, Kræftens Bekæmpelse
  • ,
  • Søren Friis, Københavns Universitet, Kræftens Bekæmpelse
  • ,
  • Deirdre Cronin-Fenton
  • Maj Britt Jensen, Rigshospitalet
  • ,
  • Bent Ejlertsen, Rigshospitalet
  • ,
  • Timothy L. Lash
  • Niels Kroman, Herlev Hospital
  • ,
  • Lene Mellemkjær, Kræftens Bekæmpelse

Background: Preclinical studies have shown both pro- and antineoplastic effects of antihistamines. Here, we evaluated the effect of H1 antihistamines on contralateral breast cancer (CBC) risk, and whether cationic amphiphilic (CAD) antihistamines could increase the sensitivity to chemotherapy. Methods: From the Danish Breast Cancer Group clinical database, we identified all women aged ≥20 years with a first-time diagnosis of breast cancer during 1996–2012. Information on drug use, CBC and potential confounding factors was retrieved from nationwide registries. Using Cox proportional hazard regression models, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for CBC associated with H1-antihistamine use. Results: We identified 52,723 patients with breast cancer with a total of 310,583 person-years of follow-up. Among them, 1444 patients developed a new primary tumour in the contralateral breast. Post-diagnosis use of H1 antihistamines (≥2 prescriptions) was not strongly associated with CBC risk (HR 1.08, 95% CI: 0.90–1.31) compared with non-use (<2 prescriptions). Use of CAD antihistamines among patients receiving chemotherapy was not associated with a decrease in CBC risk. Conclusions: Taken together, our findings do not suggest any association of H1-antihistamine use with CBC development.

OriginalsprogEngelsk
TidsskriftBritish Journal of Cancer
Vol/bind122
Nummer7
Sider (fra-til)1102-1108
Antal sider7
ISSN0007-0920
DOI
StatusUdgivet - mar. 2020

Se relationer på Aarhus Universitet Citationsformater

ID: 184627114