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The relationship between human T-lymphocyte subsets defined by monoclonal antibodies and by avidity differences to sheep erythrocytes.

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  • Institut for Medicinsk Mikrobiologi og Immunologi
By E-rosette sedimentation procedures and fluorescence activated cell sorting of monoclonal antibody-coated T lymphocytes, we have investigated the relationship between the human T lymphocyte subsets defined by the monoclonal antibodies against the T4 and T8 antigens and those defined by avidity differences to sheep erythrocytes. Through a correlation was demonstrated between the T4+ (inducer) cells and the high avidity ("active") T cells and between the T8+ (suppressor) cells and low avidity T cells, these subsets were far from identical, and it is concluded that the application of monoclonal antibodies represents another valuable and standardized approach for estimating T cell subsets.
Udgivelsesdato: 1982-Apr
OriginalsprogEngelsk
TidsskriftActa pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology
Vol/bind90
Nummer2
Sider (fra-til)105-8
Antal sider3
ISSN0108-0202
StatusUdgivet - 1982

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