The prognostic importance of miR-21 in stage II colon cancer: a population-based study

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The prognostic importance of miR-21 in stage II colon cancer: a population-based study. / Kjaer-Frifeldt, S.; Hansen, T. F.; Nielsen, B. S.; Joergensen, S.; Lindebjerg, J.; Soerensen, F. B.; Christensen, R. D.; Jakobsen, A.; Danish Colorectal Canc, Grp.

I: B J C, Bind 107, Nr. 7, 2012, s. 1169-1174.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Kjaer-Frifeldt, S, Hansen, TF, Nielsen, BS, Joergensen, S, Lindebjerg, J, Soerensen, FB, Christensen, RD, Jakobsen, A & Danish Colorectal Canc, G 2012, 'The prognostic importance of miR-21 in stage II colon cancer: a population-based study', B J C, bind 107, nr. 7, s. 1169-1174. https://doi.org/10.1038/bjc.2012.365

APA

Kjaer-Frifeldt, S., Hansen, T. F., Nielsen, B. S., Joergensen, S., Lindebjerg, J., Soerensen, F. B., Christensen, R. D., Jakobsen, A., & Danish Colorectal Canc, G. (2012). The prognostic importance of miR-21 in stage II colon cancer: a population-based study. B J C, 107(7), 1169-1174. https://doi.org/10.1038/bjc.2012.365

CBE

Kjaer-Frifeldt S, Hansen TF, Nielsen BS, Joergensen S, Lindebjerg J, Soerensen FB, Christensen RD, Jakobsen A, Danish Colorectal Canc G. 2012. The prognostic importance of miR-21 in stage II colon cancer: a population-based study. B J C. 107(7):1169-1174. https://doi.org/10.1038/bjc.2012.365

MLA

Vancouver

Kjaer-Frifeldt S, Hansen TF, Nielsen BS, Joergensen S, Lindebjerg J, Soerensen FB o.a. The prognostic importance of miR-21 in stage II colon cancer: a population-based study. B J C. 2012;107(7):1169-1174. https://doi.org/10.1038/bjc.2012.365

Author

Kjaer-Frifeldt, S. ; Hansen, T. F. ; Nielsen, B. S. ; Joergensen, S. ; Lindebjerg, J. ; Soerensen, F. B. ; Christensen, R. D. ; Jakobsen, A. ; Danish Colorectal Canc, Grp. / The prognostic importance of miR-21 in stage II colon cancer: a population-based study. I: B J C. 2012 ; Bind 107, Nr. 7. s. 1169-1174.

Bibtex

@article{543788d199374c8889ae38f030ebc6f9,
title = "The prognostic importance of miR-21 in stage II colon cancer: a population-based study",
abstract = "BACKGROUND: Despite several years of research and attempts to develop prognostic models a considerable fraction of stage II colon cancer patients will experience relapse within few years from their operation. The aim of the present study was to investigate the prognostic importance of miRNA-21 (miR-21), quantified by in situ hybridisation, in a unique, large population-based cohort. PATIENTS AND METHODS: The study included 764 patients diagnosed with stage II colon cancer in Denmark in the year 2003. One section from a representative paraffin-embedded tumour tissue specimen from each patient was processed for analysis of miR-21 and quantitatively assessed by image analysis. RESULTS: The miR-21 signal was predominantly observed in fibroblast-like cells located in the stromal compartment of the tumours. We found that patients expressing high levels of miR-21 had significantly inferior recurrence-free cancer-specific survival (RF-CSS): HR = 1.26; 95% CI: 1.15-1.60; P ",
author = "S. Kjaer-Frifeldt and Hansen, {T. F.} and Nielsen, {B. S.} and S. Joergensen and J. Lindebjerg and Soerensen, {F. B.} and Christensen, {R. D.} and A. Jakobsen and {Danish Colorectal Canc}, Grp",
year = "2012",
doi = "10.1038/bjc.2012.365",
language = "English",
volume = "107",
pages = "1169--1174",
journal = "B J C",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "7",

}

RIS

TY - JOUR

T1 - The prognostic importance of miR-21 in stage II colon cancer: a population-based study

AU - Kjaer-Frifeldt, S.

AU - Hansen, T. F.

AU - Nielsen, B. S.

AU - Joergensen, S.

AU - Lindebjerg, J.

AU - Soerensen, F. B.

AU - Christensen, R. D.

AU - Jakobsen, A.

AU - Danish Colorectal Canc, Grp

PY - 2012

Y1 - 2012

N2 - BACKGROUND: Despite several years of research and attempts to develop prognostic models a considerable fraction of stage II colon cancer patients will experience relapse within few years from their operation. The aim of the present study was to investigate the prognostic importance of miRNA-21 (miR-21), quantified by in situ hybridisation, in a unique, large population-based cohort. PATIENTS AND METHODS: The study included 764 patients diagnosed with stage II colon cancer in Denmark in the year 2003. One section from a representative paraffin-embedded tumour tissue specimen from each patient was processed for analysis of miR-21 and quantitatively assessed by image analysis. RESULTS: The miR-21 signal was predominantly observed in fibroblast-like cells located in the stromal compartment of the tumours. We found that patients expressing high levels of miR-21 had significantly inferior recurrence-free cancer-specific survival (RF-CSS): HR = 1.26; 95% CI: 1.15-1.60; P

AB - BACKGROUND: Despite several years of research and attempts to develop prognostic models a considerable fraction of stage II colon cancer patients will experience relapse within few years from their operation. The aim of the present study was to investigate the prognostic importance of miRNA-21 (miR-21), quantified by in situ hybridisation, in a unique, large population-based cohort. PATIENTS AND METHODS: The study included 764 patients diagnosed with stage II colon cancer in Denmark in the year 2003. One section from a representative paraffin-embedded tumour tissue specimen from each patient was processed for analysis of miR-21 and quantitatively assessed by image analysis. RESULTS: The miR-21 signal was predominantly observed in fibroblast-like cells located in the stromal compartment of the tumours. We found that patients expressing high levels of miR-21 had significantly inferior recurrence-free cancer-specific survival (RF-CSS): HR = 1.26; 95% CI: 1.15-1.60; P

U2 - 10.1038/bjc.2012.365

DO - 10.1038/bjc.2012.365

M3 - Journal article

C2 - 23011541

VL - 107

SP - 1169

EP - 1174

JO - B J C

JF - B J C

SN - 0007-0920

IS - 7

ER -