The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19

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The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19. / Hennings, Viktoria; Thörn, Karolina; Albinsson, Sofie et al.

I: European Journal of Immunology, Bind 52, Nr. 5, 05.2022, s. 800-809.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Hennings, V, Thörn, K, Albinsson, S, Lingblom, C, Andersson, K, Andersson, C, Järbur, K, Pullerits, R, Idorn, M, Paludan, SR, Eriksson, K & Wennerås, C 2022, 'The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19', European Journal of Immunology, bind 52, nr. 5, s. 800-809. https://doi.org/10.1002/eji.202149655

APA

Hennings, V., Thörn, K., Albinsson, S., Lingblom, C., Andersson, K., Andersson, C., Järbur, K., Pullerits, R., Idorn, M., Paludan, S. R., Eriksson, K., & Wennerås, C. (2022). The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19. European Journal of Immunology, 52(5), 800-809. https://doi.org/10.1002/eji.202149655

CBE

Hennings V, Thörn K, Albinsson S, Lingblom C, Andersson K, Andersson C, Järbur K, Pullerits R, Idorn M, Paludan SR, et al. 2022. The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19. European Journal of Immunology. 52(5):800-809. https://doi.org/10.1002/eji.202149655

MLA

Vancouver

Hennings V, Thörn K, Albinsson S, Lingblom C, Andersson K, Andersson C et al. The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19. European Journal of Immunology. 2022 maj;52(5):800-809. https://doi.org/10.1002/eji.202149655

Author

Hennings, Viktoria ; Thörn, Karolina ; Albinsson, Sofie et al. / The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19. I: European Journal of Immunology. 2022 ; Bind 52, Nr. 5. s. 800-809.

Bibtex

@article{29f5abdbb1d747f7961a80f6b7a7d5d2,
title = "The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19",
abstract = "The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T-cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, IFN-γ, and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI, and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated, or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T-cell responses including a cytotoxic CD4+ T-cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4, and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T-cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection.",
keywords = "Cytotoxic T cell, IgA, Neutralizing antibodies, Primary health care, SARS-CoV-2",
author = "Viktoria Hennings and Karolina Th{\"o}rn and Sofie Albinsson and Christine Lingblom and Kerstin Andersson and Christer Andersson and Katarina J{\"a}rbur and Rille Pullerits and Manja Idorn and Paludan, {S{\o}ren R.} and Kristina Eriksson and Christine Wenner{\aa}s",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.",
year = "2022",
month = may,
doi = "10.1002/eji.202149655",
language = "English",
volume = "52",
pages = "800--809",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "5",

}

RIS

TY - JOUR

T1 - The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19

AU - Hennings, Viktoria

AU - Thörn, Karolina

AU - Albinsson, Sofie

AU - Lingblom, Christine

AU - Andersson, Kerstin

AU - Andersson, Christer

AU - Järbur, Katarina

AU - Pullerits, Rille

AU - Idorn, Manja

AU - Paludan, Søren R.

AU - Eriksson, Kristina

AU - Wennerås, Christine

N1 - Publisher Copyright: © 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

PY - 2022/5

Y1 - 2022/5

N2 - The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T-cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, IFN-γ, and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI, and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated, or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T-cell responses including a cytotoxic CD4+ T-cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4, and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T-cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection.

AB - The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T-cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, IFN-γ, and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI, and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated, or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T-cell responses including a cytotoxic CD4+ T-cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4, and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T-cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection.

KW - Cytotoxic T cell

KW - IgA

KW - Neutralizing antibodies

KW - Primary health care

KW - SARS-CoV-2

UR - http://www.scopus.com/inward/record.url?scp=85124724365&partnerID=8YFLogxK

U2 - 10.1002/eji.202149655

DO - 10.1002/eji.202149655

M3 - Journal article

C2 - 35128644

AN - SCOPUS:85124724365

VL - 52

SP - 800

EP - 809

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 5

ER -