The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Viktoria Hennings, University of Gothenburg
  • ,
  • Karolina Thörn, University of Gothenburg
  • ,
  • Sofie Albinsson, University of Gothenburg
  • ,
  • Christine Lingblom, University of Gothenburg
  • ,
  • Kerstin Andersson, University of Gothenburg
  • ,
  • Christer Andersson, Nötkärnan Primary Health Care Center Consortium
  • ,
  • Katarina Järbur, Nötkärnan Primary Health Care Center Consortium
  • ,
  • Rille Pullerits, University of Gothenburg
  • ,
  • Manja Idorn
  • Søren R. Paludan
  • Kristina Eriksson, University of Gothenburg
  • ,
  • Christine Wennerås, University of Gothenburg

The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T-cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, IFN-γ, and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI, and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated, or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T-cell responses including a cytotoxic CD4+ T-cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4, and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T-cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Immunology
Vol/bind52
Nummer5
Sider (fra-til)800-809
Antal sider10
ISSN0014-2980
DOI
StatusUdgivet - maj 2022

Se relationer på Aarhus Universitet Citationsformater

ID: 269165871