The POSEIDON Criteria and Its Measure of Success Through the Eyes of Clinicians and Embryologists

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Sandro C Esteves, ANDROFERT-Andrology and Human Reproduction Clinic & University of Campinas (UNICAMP), Campinas, Brazil.
  • ,
  • Carlo Alviggi, Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
  • ,
  • Peter Humaidan
  • Robert Fischer, Fertility Center Hamburg, Hamburg, Germany.
  • ,
  • Claus Y Andersen, Københavns Universitet
  • ,
  • Alessandro Conforti, Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
  • ,
  • Klaus Bühler, Department of Gynaecology, Jena-University Hospital-Friedrich, Schiller University, Jena, Germany.
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  • Sesh K Sunkara, Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine, King's College London, London SE1 8WA, United Kingdom.
  • ,
  • Nikolaos P Polyzos, Dexeus University Hospital, Barcelona, Spain.
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  • Daniela Galliano, Instituto Valenciano de Infertilidad, Rome, Italy.
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  • Michael Grynberg, Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Antoine Béclère, Clamart, France.
  • ,
  • Hakan Yarali, Anatolia IVF, Ankara, Turkey.
  • ,
  • Irem Y Özbek, Anatolia IVF, Ankara, Turkey.
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  • Matheus Roque, ORIGEN - Center for Reproductive Medicine, Rio de Janeiro, Brazil.
  • ,
  • Lan N Vuong, IVFMD, My Duc Hospital, 4 Nui Thanh Street, Tan Binh District, Ho Chi Minh City, Vietnam.
  • ,
  • Manish Banker, Nova IVI Fertility, Ahmedabad, India.
  • ,
  • Laura Rienzi, GENERA, Center for Reproductive Medicine, Rome, Italy.
  • ,
  • Alberto Vaiarelli, GENERA, Center for Reproductive Medicine, Rome, Italy.
  • ,
  • Danilo Cimadomo, GENERA, Center for Reproductive Medicine, Rome, Italy.
  • ,
  • Filippo M Ubaldi, GENERA, Center for Reproductive Medicine, Rome, Italy.

This article represents a viewpoint on the POSEIDON criteria by a group of clinicians and embryologists. Its primary objective is to contextualize the Poseidon criteria and their metric of success for the relevant Frontiers Research Topic "POSEIDON's Stratification of Low Prognosis Patients in ART: The WHY, the WHAT, and the HOW". "Low prognosis" relates with reduced oocyte number, which can be associated with low or sometimes a normal ovarian reserve and is aggravated by advanced female age. These aspects will ultimately affect the number of embryos generated and consequently, the cumulative live birth rate. The novel system relies on female age, ovarian reserve markers, ovarian sensitivity to exogenous gonadotropin, and the number of oocytes retrieved, which will both identify the patients with low prognosis and stratify such patients into one of four groups of women with "expected" or "unexpected" impaired ovarian response to exogenous gonadotropin stimulation. Furthermore, the POSEIDON group introduced a new measure of clinical success in ART, namely, the ability to retrieve the number of oocytes needed to obtain at least one euploid blastocyst for transfer in each patient. Using the POSEIDON criteria, the clinician can firstly identify and classify patients who have low prognosis in ART, and secondly, aim at designing an individualized treatment plan to maximize the chances of achieving the POSEIDON measure of success in each of the four low prognosis groups. The novel POSEIDON classification system is anticipated to improve counseling and management of low prognosis patients undergoing ART, with an expected positive effect on reproductive success and a reduction in the time to live birth.

OriginalsprogEngelsk
Artikelnummer814
TidsskriftFrontiers in Endocrinology
Vol/bind10
Antal sider8
ISSN1664-2392
DOI
StatusUdgivet - 2019

Bibliografisk note

Copyright © 2019 Esteves, Alviggi, Humaidan, Fischer, Andersen, Conforti, Bühler, Sunkara, Polyzos, Galliano, Grynberg, Yarali, Özbek, Roque, Vuong, Banker, Rienzi, Vaiarelli, Cimadomo and Ubaldi.

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